ASH VALUES

MASTER OF PHARMACY

Guided by:- Submited by:-

MR. ANKUSH SUNDRIYAL PRAVEEN SISODIYA

ASSISTANT PROFESSOR

SCHOOL OF PHARMACEUTICAL SCIENCES AND TECHNOLOGY

SARDAR BHAGWAN SINGH POST GRADUATE INSTITUTE OF BIOMEDICAL SCIENCES AND REASEARCH
BALAWALA,DEHRADUN (U.K.), INDIA
2019
 EVALUATION OF CRUDE DRUGS

 Drug evaluation may be define as the determination of identity, purity and

quality of drug.
 Importance of evaluation of crude drug:-

a.Determination of biochemical variation in the drug.

b. Identification of deterioration due treatment and storage.
 METHODS OF DRUG EVALUATION

 The various methods are:-

1. Orgenoleptic evaluation
2. Microscopic evaluation
3. Physical evaluation
4. Chemical evaluation
5. Analytical evaluation
6. Biological evaluation
 PHYSICAL EVALUATION

 Moisture content
 Ash value
 Swelling index
 Extractive values
 Melting point
 Solubility
 Viscosity
 ASH VALUES

 The residue remaining after insineration is the ash content of the drug.
 It may be organic salts of carbonates, phosphates, potassium, calcium,
magnesium.
 Ash value is a method to judge the purity of the drug.
 TYPES OF ASH VALUES

 Total ash value

 Acid insoluble ash value
 Sulphated ash value
 Water soluble ash value
 TOTAL ASH VALUE

 Useful for detecting low grade products.

 Useful for detecting excess of sandy.
 Usedul for detecting earthy matter with drug.
 Useful for detecting exhausted drug.

*DETERMINATION:-
Weigh accurately about 3gm of the powder drug

Incinirate the drug by gradually increasing the heat until free from carbon and cool

weigh the ash and calculate the % of the total ash with reference to air dried sample
 ACID INSOLUBLE ASH VALUE
 Use for the determination of earthy matter present on roots, rhizomes, and also on
the leaves.
 Crude drug contain calcium oxalate crystals the amount may varies depending on
the environmental condition.

* DETERMINATION:-
Boil the total ash obtaines as above for 5 minutes with 25 ml of dilute HCL

Filter and collect the insoluble matter on ashless filter paper

Wash the filter paper and ignite on tared crucible and cool

Weigh the residue and calculate the acid insoluble ash

 SULPHATED ASH VALUE

 Used for the detection of low grade products

 WATER SOLUBLE ASH VALUE

 Used to detect either material exhausted by water or not

(Tea leaves, Ginger rhizomes)
THANK YOU