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Bone
Bone
AND
CARTILAGE
BONE
FUNCTION:
• STRUCTURAL SUPPORT
• LOCOMOTION
hemopoiesis
ORGANIC : MAINLY PROTEINS
BONE
OSTEOCLASTS : resorption
OSTEOBLASTS : deposition
OSTEOCYTES : maintenance of
bone matrix
MAJOR CELLS PRESENT IN MEMBRANOUS BONE
OSTEOCLAST
STIMULATE INHIBIT
O PTH
S
T 1,25-Dihydroxycholecalciferol Corticosteroids
E T3,T4
O
B hGH, IGF-1
L PGE2
A
S TGF
T Estrogens?
S
O
S PTH Calcitonin
T 1,25-Dihydroxycholecalciferol Estrogens (by inhibiting IL-6
E
IL-1, IL-6 production)
O
TNF TGF
C
L TGF IFN
A PGE2
S
T
S
MOLECULAR ORGANIZATION IN CARTILAGE MATRIX
SCHEMATIC DIAGRAM OF AGRECAN