PH CONTROLLED DRUG

DELIVERY
IQRA REHMAN
 CONTROLLED DRUG DELIVERY
• Controlled drug delivery is one which delivers
the drug at a predetermined rate, for locally or
systemically, for a specified period of time.
• Challenges in Oral Drug Delivery
PH CONTROLLED DRUG DELIVERY SYSTEM

• This type of DDS permits targeting the delivery

of a drug only in the region with a selected pH
range.
• Most drugs are either weak acids or weak
bases, their release from formulation is pH
dependent
 FEATURES
This type of system is designed for the
controlled release of acidic or basic drugs in GIT
at a rate independent of the variation in GI-pH
with sufficient buffering agents.
 PREPARATION
(USING BUFFER)
• It is prepared by first blending an acidic (or
basic) drug with one or more buffering
agents, e.g. a primary, secondary, or tertiary
salt of citric acid
• Granulating with appropriate excipients to
form small granules,
• Then coating the granules with GI polymer .
 USING POLYMER
• Making a core tablet
• Coating a core tablet with a combination of
1. Intestinal fluid-insoluble polymers. Example-
ethyl cellulose
2. Intestinal fluid soluble polymer . Example-
methyl cellulose
INTESTINAL PH ACTIVATED DDS
ADVANTAGE
• More uniform drug effect
• Reducing dose frequency
• Improved efficacy and safety ratio

DISADVANTAGE
• Dose dumping
• Stability problem