MEERWEIN-PONNDORF-VERLEY REDUCTION (MPV)

16 INTRODUCTION

🠶 MPV reduction is the reduction of aldehyde and ketones to their

corresponding alcohols utilizing Aluminium oxide catalysis in the
presence of sacrificial alcohol.
🠶 MPV reduction was discovered by Meerwein and Schmidt and
separated by Verley in 1925.They found that the mixture of
aluminium oxide and ethanol could reduce aldehyde to alcohols.
🠶 Pondroff applied the reaction to ketones and upgraded the catalyst to
aluminium isopropoxide in isopropanol.
17 GENERAL REACTION

🠶 Conversion of aldehyde or ketone in to corresponding alcohol by

treatment with Aluminium isopropoxide in isopropanol solution.
🠶 This reaction is reversible and is called Oppenauer oxidation.
18 MECHANISM
19 MODIFICATION

🠶 A modified MPV reduction has been developed which results in

extremely rapid conversion of aldehyde and ketones
corresponding carbinols at room temperature to by
(TrifluroAceticacid) to Aluminium isopropoxide adding TFA
(AIP).
20 APPLICATIONS

🠶 This method of reduction is specific carbonyl group and

therefore it for can be used for aldehydes and
containing some reducing
other reducible group, such
ketones
as, a double bond, a
nitro or an ester group, which are not reduced under these
conditions.
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22  Used in synthesis of oestradiol