Bone Mineralization

Presented by:
Yohanes Satrio, S.Ked.

Advisor:
Dr. Nur Kholis, Sp.OT
Bone Function
 Support
 Protection
 Leverage
Bone Composition
The Matrix : Type I collagen, Other non-collagenous
proteins, Growth factor, Bone morphogenetic protein
Bone Mineral : Calcium, Phosphate
Bone Cells : osteoblasts, osteocytes and osteoclasts.
Bone Development and Growth
Endochondral Ossification
Intramembranous Ossification
Endochondral Ossification
Usual manner in which tubular bones develop
The physis consists of four distinct zones:
1. Zone of resting chondrocytes
2. Proliferative zone
3. Hypertrophic zone
4. Zone of calcified cartilage
Intramembranous Ossification
Mesenchymal cells differentiate into osteoblasts and
old bone is removed from the inside of the cylinder by
osteoclastic endosteal resorption
Intramembranous periosteal new bone formation also
occurs as a response to periosteal stripping due to
trauma, infection or tumour growth, and its
appearance is a useful radiographic pointer
Bone Resorption
Carried out by the osteoclasts under the influence of
stromal cells (including osteoblasts) and both local
and systemic activators
Promoted by PTH
Bone Modelling and Remodelling
The sequential process of bone resorption and
formation has been likened to sculpting
Old bone replaced by new bone
Bone Mineralization Aspect
Calcium
Phosphorus
Magnesium
Vitamin D
Parathyroid Hormone
Calcitonin
Gonadal Hormones
Vit D Regulation