Princess Mononoke

Princess Mononoke follows the journey of the last Emishi prince, Ashitaka

, and his attempts to make peace between the human settlement, Irontown,
and the creatures living in the forest that surrounds it. The film begins with
Ashitaka saving his village from a vicious assault by killing a demon who
is actually the giant boar god Nago embodied by rage. During the fight,
Ashitaka receives a demon mark on his right arm, and he is cursed by the
Boar God's hatred and pain. Ashitaka is told that the mark will spread
throughout his body, killing him. A ball of iron is found inside Nago's
corpse, which is somehow connected to the curse. 
 Ashitaka resolves to journey to Nago's origin, the lands to the
West, to try and find a cure for his curse. He cuts his hair,
signifying his permanent departure from his village, and rides
out with Yakul, his loyal red elk. Since it was considered taboo
to see off one who is banished, only one person dared to say
goodbye to Ashitaka: his 'little sister,' Kaya (according to
Miyazaki, actually his bride-to-be; calling herself his 'little
sister' was a term of affection), who gives him her crystal
dagger so that he would not forget her.
Having traveled some distance, Ashitaka arrives in a forest full of
animal gods, including the wolf god Moro. Also in the forest is
the Forest Spirit, described as a "god of life and death", which
takes the form of a deer during the day and a large shadowy
"night-walker" at night.
 he forest lies beside a human settlement called Irontown which
continually clears the forest to get to more iron ore, causing
many battles as the animals attempt to protect their diminishing
forest. It was during one of these battles that Irontown's leader,
Lady Eboshi, shot Nago.
During the film Ashitaka travels between the forest and
Irontown several times, trying to make peace. During Ashitaka's
first visit, the village is attacked by San, a human girl who has
been adopted by the wolves. Ashitaka intervenes to stop the two
sides fighting and takes San back to the forest, but is injured in
the process. With San's intervention, he is healed of his wounds
— but not his curse — by the forest spirit.
 Under the influence of Jigo, Eboshi sets out to destroy the
Forest Spirit. The head of the Forest Spirit is believed to grant
immortality; Jigo plans to give the head to the emperor; in
return the emperor promises to give Irontown legal protection
against the envious daimyos coveting the town's prosperity.
Eboshi, however, suspects (rightly) that the emperor's agents
are also assigned to take control of Irontown at the most
opportune moment.
Despite Ashitaka's efforts, Eboshi succeeds in cutting off the
Forest Spirit's head while it is transforming. Jigo collects the
head while the body is transformed into a god of death, as a
result the land becomes covered with a lethal black ooze, that
completely destroys the forest and turns the land barren. To
stop the spreading ooze from reaching the villagers, Ashitaka
and San manage to take the head from Jigo and by returning
the head to the Forest Spirit, the land becomes green again, and
Ashitaka's curse is finally lifted.