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BASIC TISSUES
Epithelium
Connective tissue
Muscular tissue
Nervous tissue
Organs divided into:
Parenchyma –cells
Stroma –supporting tissue
SIMPLE SQUAMOUS EPITHELIUM
Composed of very thin flat
irregular shaped cell that form
a continuous surface
Also called pavement
epithelium
Found in:
Lining of blood & lymph
vessels
Alveoli of lungs
Parietal layer of Bowman’s
SIMPLE CUBOIDAL EPITHELIUM
Cells appear cube or box like
Nucleus is rounded & placed in
centre of cell
cells rest on basement
membrane
Present in:
Follicles of thyroid gland
Distal convoluted tubules of kidney
FUNCTION
Absorption
SIMPLE COLUMNAR NON
CILIATED EPITHELUIUM
Composed of tall columnar
cells
Rests on basement
membrane
Nucleus in elongated & lies
in basal half of cell
Apical surface of cells may
have microvilli which give
apperance of brush border
Found in:
Lining of GIT
FUNCTIONS:
Absorption
SIMPLE COLUMNAR CILIATED
EPITHELIUM
CILIA present on surface of
simple columnar epithelium
Present in:
Small intrapulmonary bronchi
Simple columnar non-ciliated
cells may be present between
ciliated cells
Example :
Uterine tube
PSEUDOSTRATIEIED EPITHELIUM
NON-CILIATED
Variant of simple columnar
epithelium
Tall & short cells are present
All cells rest on basement
membrane
Nuclei disposed at different
levels
Present in;
Parts of male urethra
PSEUDOSTRATIEIED EPITHELIUM
CILIATED
This epithelium
goblet cells
Example:
Trachea
Larger bronchi
STRATIFIED EPITHELIA
STRATIFIED SQUAMOUS NON
KERATINIZEXEPITHELIUM
Multi-layered
Basal layer low columnar or high
cuboidal
This layer divides
Subsequent layers polygonal
Surface layers flattened
Underlying connective tissue raised
into ridges
Examples :
Oesophagus
Anal canal
Cervix
STRATIFIED SQUAMOUS
KERATINIZED EPITHELIUM
Features same as
non-keratinized
epithelium except
Surface layer
composed of non-
nucleated cells
They acquire
protein keratin
Example :
Skin
TRANSITIONAL EPITHELIUM
IN RELAXED STATE
Is 4-5 cell layer thick
Basal layer is cuboidal
Intermediate layer is
polyhedral
surface layer is cuboidal
with binucleate cells
IN STRETCHED STATE
Is 2-3 cell thick
Surface layer is squamous
Example :
urinary tract
STRATIFIED CUBOIDAL
Consists of two
layers of cuboidal
cells
Cells of superficial
layer are smaller
Examples :
Ducts of salivary
glands
Ducts of sweat
STRATIFIED COLUMNAR EPITHELIUM
Basal layer consists of low columnar or cuboidal cells
Surface layer is of tall columnar cells
Examples :
Conjunctiva
Parts of male urethra
ENDOTHELIUM
Lines all blood & lymph channels
MESOTHELIUM
Lining of pleura, pericardium & peritoneum
CONNECTIVE TISSUE
Characterized by the presence of relatively few cells & abundant
intercellular substance
FUNCTIONS
STRUCTURE
Cells
Fibres
Ground substance
Fibroblasts
Mast cells
Plasma cells
Macrophages (histiocytes)
Leukocytes
Adipocytes
MESENCHYMAL CELLS
FIBROBLASTS
MACROPHAGES
PLASMA CELLS
MAST CELLS
ADIPOCYTES
FIBERS OF CONNECTIVE
TISSUE
Collagen
Elastic
Reticular
COLLAGEN FIBERS
ELASTIC FIBERS
RETICULAR FIBRES
GROUND SUBSTANCE
Glycosaminoglycans (mucopolysaccharides)
Proteoglycans
Multiadhesive glycoproteins
TYPES OF CONNECTIVE
TISSUE
Embryonic connective tissue
Mesenchyme
Mucous
Adult connective tissue
Connective tissue proper
Loose
Dense
Irregular
Regular
Specialized
Reticular
Adipose
Bone
Cartilage
LOOSE CONNECTIVE TISSUE &
DENSE IRREGULAR CONNECTIVE
TISSUE
DENSE REGULAR CONNECTIVE
TISSUE
RETICULAR TISSUE
EMBRYONIC CONNECTIVE TISSUE
MESENCHYME MUCOUS
CARTILAGE
Cells (chondrocytes)
Extra-cellular matrix
Fibrils
Ground substance
Proterglycan
Glycosaminoglycanp (mucopolysaccharide)
TYPES OF CARTILAGE
Hyaline
Elastic
Fiibrocartilage
HYALINE CARTILAGE
ELASTIC CARTILAGE
FIBROCARTILAGE
BONE
Cells
Osteocytes
Osteoblasts
Osteoclasts
Bone matrix
Organic
Collagen type 1
Ground substance
Proteoglycans
Glycoproteins
Inorganic
Hydroxyapatite
Ca Po4, magnesium, bicarbonate, citrate, sodium & potassium
TYPES OF BONE
(GROSS OBSERVATION)
TYPES OF BONE
(MICROSCOPIC EXAMINATION)
Skeletal muscle
Smooth muscle
Cardiac muscle
ORGANIAZATION OF SKELETAL
MUSCLE
Endomysium – muscle fiber
Perimysium – fascile
Epimysium – entire muscle
ORGANIZATION OF SKELETAL
MUSCLE
SKELETAL MUSCLE
CARDIAC MUSCLE
CARDIAC MUSCLE
SMOOTH MUSCLE
SMOOTH MUSCLE
COMPARISON BETWEEN THE THREE
TYPES OF MUSCLES
NERVE TISSUE & NERVOUS
SYSTEM
Central nervous system
Brain & spinal cord
Peripheral nervous system
Spinal, cranial & peripheral nerves
ganglia
Nerve cells (neuron)
Glial cell (supporting cells)
STRUCTURE OF NEURON
Cell body
Axon
dendrite
GLIAL CELLS
CNS
Oligodendrocytes
Ependymal cells
Astrocytes
Microglial cells
PNS
Neurolemmocytes
(Schwann cells)
PERIPHERAL NERVOUS
SYSTEM
COMPONENTS OF PNS
• Nerves
• Ganglia
• Nerve endings.
CONNECTIVE TISSUE COMPONENTS OF A
PERIPHERAL NERVE:
• Endoneurium: constitues the loose c.t associated
with individual nerve fiber. It merges with an
external lamina of IV collagen ,laminin and other
proteins produced by schwann cells. Other cells
are fibroblasts and mast cells.
•
Perineurium is a specialized
c.tissue surrounding a nerve
fascicle. It serves as a
metabolically active diffusion
barrier that contribute to the
formation of blood –nerve
barrier. It may be one or two
cell thick depending on the
nerve diameter .It is formed by
layers of flattened epithelial
cells. The cells of each layer of
the perineurium are joined at
their edges by tight junctions
•
Epineurium consists of dense
irregular c .tissue that surround
and binds nerve fascicles into
a common bundle. Blood
vessels that supply the nerve
travel in epineurium.
GANGLIA
• It is an ovoid structures
contain neuronal cell bodies
and glial cells supported by
c.tissue.
• Serves as relay stations to
transmit nerve impulses.
Types of ganglia:
• Sensory ganglia: They
receive afferent impulses
that go to the CNS. They
are associated with cranial
nerves called cranial
ganglia, and the dorsal root
of spinal nerves called
spinal ganglia
•
continued….
Connective tissue capsule which is continuous with the
epineurium of nerve on which ganglion is situated Ganglion
cells are neurons of pseudounipolar type. Each neuron
gives rise to a single process which makes several irregular
turns around the cell body and bifurcate in a T- shaped
manner. One branch acts as dendrite and pass in a spinal or
cranial nerve to periphery and terminate at a receptor and
other branch act as functional axon and passes to CNS. Size
of nerve cell body varies. Small cell bodies give rise to
unmyelinated processes, large perikarya give origin to
myelinated processes. Nerve cell bodies are arranged as
groups in peripheral zone of ganglion and surrounded by a
single layer of low cuboidal cells called satellite cells. The
central zone is devoid of nerve cell bodies and contain nerve
fibers.
•
AUTONOMIC
They are associated with
GANGLIA
sympathetic and parasympathetic
division of autonomic nervous
system.
•
Arranged as small bulbous
dilatations in autonomic nerves.
•
Located in certain organs
especially in the wall of GIT called
intrameural ganglia.
• Covered by less well developed c.
tissue capsule.
• Multipolar neuron which are
evenly distributed.
• Covered by a layer of satellite
cells.
• Parasympathetic ganglia lacks
distinct capsule, perikarya and
associated satellite cells form a
loosely organized plexus within
the surrounding c .tissue.
STRUCTURE OF THE
CEREBRAL CORTEX
The cerebral cortex
forms a complete
covering of the cerebral
hemisphere. It is
composed of gray
matter and contains
approx. 10 million
neurons. The gray
matter contains nerve
cells, neuroglia and
blood vessels. The
following types of nerve
cells are present in the
PYRAMIDAL CELLS
Contains a large vesicular
nucleus
Abundant nissl granules
One main dendrite arises
from the apex and ends in
the most superficial layer of
the cortex.
Four or more branching
dendrite pass outward from
the base of the perikaryon.
Axon emerges from the
center of the base and runs
into the underlying white
matter.
Nonpyramidal cells
Stellate/granule cells: small polygonal
perikaryon; each cell gives off a number of small
dendrites passing in various direction and a short
axon which ramifies close to the cell body; most of
the extrinsic inputs to the cerebral cortex terminate
on the dendrites of the stellate cells.
Horizontal cells of cajal: small, fusiformed,
horizontally oriented; found in the most superficial
cortical layer; has many short dendrites and a long
axon which runs parallel to the surface of the cortex
making contact with the dendrites of the pyramidal
cells.
CONTINUED
Martinotti cells: small, multipolar cells found in
the deeper layers of the cerebral cortex; has a
short dendrite but the long axon ascends towards
the cortical surface to end in a more superficial
layer.
Fusiform cells. They have long axis vertical to
the surface and concentrated mainly in the deeper
cortical layers.Dendrites arise from each pole of
the cell body and ascend toward the surface of the
surface of the cortex and branch in the superfical
layers. The axon arises from the inferior pole of
cell body and enter the white matter as a
LAYERS OF THE CEREBRAL
CORTEX
Endoneurium
Perineurium
epineurium
CIRCULATORY SYSTEM
Heart
Arteries
capillaries
Veins
Blood Vessel Tunics
Tunica Intima, or Tunica Interna
innermost layer
composed of:
an endothelium (simple squamous epithelium)
subendothelial layer (areolar CT)
Tunica Media
middle layer of the vessel wall
composed of:
circularly arranged smooth muscle cells
Sympathetic innervation:
Increase: vasoconstriction (narrowing of the blood vessel
lumen)
Decrease: vasodilation (widening of the blood vessel lumen)
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Blood Vessel Tunics
Tunica Externa, or Tunica Adventitia
outermost layer
composed of:
areolar connective tissue that contains elastic and collagen fibers
helps anchor the vessel to other tissues
Term adventitia is used to specify outer layer in blood vessels that
are buried in CT
Vasa vasorum : blood vessels that supply large blood vessels
In the externa
Arteries vs Veins:
Media largest in arteries, externa largest in veins
Lumen is smallest in arteries
Artery wall have more elastic and collagen fibers
Capillaries: only the Interna
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Arteries
In the systemic circulation, carry oxygenated
blood to the body tissues.
Pulmonary arteries carry deoxygenated blood
to the lungs.
Three basic types of arteries:
elastic arteries, muscular arteries, and arterioles
as an artery’s diameter decreases
corresponding decrease in the amount of elastic fibers
relative increase in the amount of smooth muscle
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Capillaries
Contain only the tunica intima, but this layer consists
of a basement membrane and endothelium only.
Allow gas and nutrient exchange between the blood
and the body tissues to occur rapidly.
Smallest blood vessels, connect arterioles to venules.
Are called the functional units of the cardiovascular
system.
A group of capillaries (10–100) functions together and
forms a capillary bed.
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STRUCTURE OF BLOOD
VESSELS
Endothelium
Smooth muscle
Connective tissue
Collagen fibers
Elastic fibres
Tunica intima
Tunica media
Tunica adventitia
ARTERIES
Elastic artery
Muscular aryery
Arterioles
Capillaries
ELASTIC ARTERY
MUSCULAR ARTERY
ARTERIOLE
CAPILLARIES
STRUCTURE OF VEINS
VEINS
Venules
Medium sized veins
Large sized veins
SMALL VEIN
MEDIUM SIZED VEIN
LARGE VEIN
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