Prebiotic UG1601 mitigates constipation-related events in

association with gut microbiota:

A randomized placebo-controlled
intervention study
Introduction
• Constipation is one of the most common functional disorder
• Characterize as one or more symptoms:
• Hardened stools
• Infrequent evacuation
• Uncomfortable senese of incomplete evacuation
• Execessive time spent for successful defecation
• Etiology are multifactorial
• Prebiotics undergo bacterial fermentation tat may produce Short chaine
fatty acid (butyrate) can change stool consistency
• UG1601: Inulin, lactitol, and aloe vera gel which are known laxative
Summary:
• Among participants aged (18-60 y.o) with constipation what is the
effect of UG1601 supplementation versus placebo, in attaining
alleviation of symptom score and endotoxemia through randomized,
double blinded, placebo-controlled and parallel study design
Results
Conclusion:
• Supplementation with UG1601 with mild constipation improved stool
frequency and suppressed endotoxemia
• Decrease in the abundance of phylum Firmicutes and increase in
butyrate-producing bacteria may reduce available LPS which can
regulate intestinal motility and lower endotoxemia