Neiry María Zapa Pérez

Médica
Servicio de neurología
Hospital Simón Bolívar
 Introduction
• Disability
• 850.000 🡪2015
• 2 millions🡪2051
• > 65 years
• Common infections*
• Diabetes
Previous studies:
Sepsis – Pneumonia
Follow-up 3-5 years
5955 participants
Inadequate adjustment for confounding
Methods
Evidence
Hipotesis:before this study
All common infections > Risk of dementia
Diabetes
Systematicmodified
Review association between infections and dementia

Longitudinal studies

The association between common bacterial infections and dementia or cognitive decline

Embase and MEDLINE, March 1, 2019 and Dec 22, 2020

Language or geographical location restrictions 

2 New studies, USA or Taiwan. One study did not find an association  🡪 UCI
Methods
Database UK -Clinical Practice Research Datalink (CPRD) linked to secondary care data from the Hospital
Episode Statistics (HES). 

Included: adults aged 65 years and older 

Individuals who were registered in CPRD at least 12 months before the start of follow-up and who had no
history of dementia or cognitive impairment 

Registered in CPRD between Jan 1, 2004, and Dec, 31, 2018 

Delirium: we excluded the first 3 months of follow-up after infection  

Sepsis, pneumonia, other lower respiratory tract infections, urinary tract infections, and skin and soft tissue
infections. 
Methods
Tiempo
Statistical analysis 

Cox proportional hazards regression 

IC 95% -Association between co mmon infections and risk of dementia  Status

- 3 months to <1 year
- 3 months to <2 years
Excluded: - 3 months to <3 years
Individuals with
- 3secondary
months todementia
<4 years causally related to other conditions 
Codes relating
- to symptoms
3 months of cognitive
to <5 years impairment
Individuals diagnosed withtoinfections No infection Infectio n
- 3 months <6 years from two different sites 
- 3 months to <7 y ears
- 3 months to <8 years
A p value of less
- 3than 0·05 was considered to be statistically significant
months to <9 years 
 Association between
infections and dementia
varied by sex

Association between
infections and dementia
Proximity to death after
differed across subtypes
dementia diagnosis in
of dementia (Alzheimer’s
people with and without
disease, vascular
infections 
dementia, and
unspecified dementia) 

secondary
analyses: 
Results
Results
Results
Results
Discussion

Common infections
were associated Sepsis and
with an increased pneumonia. 
risk of dementia 

Infections resulting
in hospital
admission were
associated with Conclusion
approximately
double the risk of
dementia