COSVAT

When chemistry and costs matter

 PRESERVATIVE

 Definition:
 Preservative are used to maintain quality and ensure a
formulation; are microbiologically safe and stable; added to
protect, prevent, or retard decay, discoloration, or spoilage
under conditions of use or storage. Preservatives also extend
a product’s shelf life.
 PRESERVATIVE
 Why do we need preservatives?
 Microbial contamination can cause: -
 Loss of product viscosity
 Drop in pH
 Emulsion breakdown
 Cloudiness and visible growth
 Loss of colour
 Malodour
 Skin problems
 PRESERVATIVE
 What makes a good preservative?
 The ideal preservative should have the following attributes :-
 Broad-spectrum activity against bacteria, yeast and moulds
 Cidal rather than static activity
 Sufficient speed of kill to satisfy accepted challenge test criteria
 Be stable and effective over the anticipated shelf life of the
product
 Be safe to handle and preferably liquid
 Be safe at use concentrations
 Be effective over the pH range of the product
 Be cost effective
 COSVAT (Chlorphenesin)
 Chlorphenesin is one of the newest preservative agents to
make an appearance in the personal care industry. It has been
widely used in the pharmaceutical industry for many years.
When Chlorphenesin is combined with other preservative
actives, overall performance is boosted. This effect,
combined with widespread acceptance and broad application,
makes Chlorphenesin-based preservatives an attractive
addition to your formulation library.
 COSVAT PRODUCT INFORMATION

 Molecular Weight : 202.64

 Name of the product : COSVAT (Chlorphenesin)
 Chemical Name : 3-(4-Chlorphenoxy)-1,2-Propane-diol.
 INCI Name : Chlorphenesin
 USAN Nomenclature : Chlorphenesin
 CAS No : 104-29-0
 EINECS : 203-192-6
 
STRUCTURE OF COSVAT

C9 H11Cl O3
 APPLICATIONS

 Chlorphenesin has antifungal and antibacterial characteristics.

 Preservation and stabilization of cosmetics.
 Chlorphenesin powder 1% applied to the skin and sprinkled in the
clothing and bedding, prevented the formation of ammonia and
other odors in children suffering from bed-wetting.
 PERFORMANCE SUMMARY
 An effective anti-bacterial and anti-fungal agent
 Boosts preservative effectiveness to a higher level
 When Chlorphenesin is used in conjunction with other
antimicrobial, overall preservation effectiveness is increased. 
 PRODUCT SPECIFICATIONS
S.NO PROPERTY SPECIFICATION

01. Description White to Off-white Crystalline aggregates

 
02. Odor Slight Phenolic odour

03. Melting Range 78 to 81

(In o C)
04. Identification The IR spectrum of the Sample should be
concordant With the standard.

05. Assay by Chemical Not less than 99.0

  method (%W/W)
 SOLUBILITY
SOLVENT SOLUBILITY
Water Less than 1%.
Alcohol Soluble
Ether Soluble
Acetone Freely soluble
Chloroform Freely soluble
Benzene Freely soluble
Fixed oils Slightly soluble
 MICROBIOLOGY

S. No TEST RESULT

01. Total Aerobic Microbial Count NIL

02. Total Fungal Count NIL

03. E.coli Negative
04. Salmonellae Negative
05. Ps.aeruginosa Negative
06. S.Aureus Negative
 COSVAT
IMPURITY PROFILE
 
S.No Organic Impurity Result (in ppm)

01. Chlorophenol Less than 10ppm

02. Di-Chloromethane Nil

03. Toluene 1.6ppm

 COSVAT
HEAVY METALS

S.No Metals Result (in ppm)

01. Mercury 0.32ppm

02. Arsenic 1.5ppm

03. Lead 4.1ppm

 SAFETY PROFILE
      

NAME FIRST AID MEASURES

 

Eye Contact In case of contact with eyes, flush immediately with

plenty of water. If easy to do, remove contact lenses.
Get medical attention

Ingestion Induce vomiting as directed by medical personnel.

Never give anything by mouth to an unconscious
person. If swallowed, seek medical advice
immediately and show the container or label.
 TOXICITY PROFILE
 Ingestion :
 Harmful if swallowed
 Skin Contact :
 Practically Non-Toxic
 Skin Irritation :
 Skin contact with the concentrate may cause slight irritation characterized by
redness. This irritant effect would be expected to be completely reversible
with no permanent damage.
 Eye Irritation :
 Eye contact with the concentrate may cause moderate irritation that could
consist of redness, swelling, and mucous membrane discharge. Any visual
effects would be expected to clear within a Few days with no permanent
impairment.
 TOXICITY PROFILE
 Inhalation :
 Not classified as dangerous according to EC directives
 Skin Sensitization :
 Does not cause allergic skin reactions, Not classified as
dangerous according to EC directives. BP 73 has approved
the compound for topical administration in the treatment of
fungal infections.
 Chronic Health Concerns:
 This product is not known or reported to be carcinogenic by
any reference source including IARC, OSHA, NTP or EPA
 OTHER INFORMATION
 Disclaimer :
 The information provided in this Sheet is gathered from
reliable and well-published sources to the best of our
knowledge, information and belief on the date of its collation,
release and is not to be considered a warranty or quality
specification.
  Information is supplied upon the condition that the receivers
will make their own determination as to its suitability for
their purposes prior to use. In no event will VIVIMED LABS
LIMITED be responsible for damage of any nature
whatsoever resulting from the use of or upon reliance of the
information.
THANK YOU

When chemistry and costs matter