Professional Documents
Culture Documents
Learning Objectives
• Influenced by
– Dates drug first used in humans
– Penetration into local marketplace (changes in
cost, regulatory approval)
– Evolution of National TB Program (NTP) regimens
– Introduction of free-of-charge Rx
– Availability as OTCs
Anti-TB Drugs
First-Line Second-Line
Drug Frequency
Isoniazid 1/1,000,000
Pyrazinamide 1/1,000,000
Streptomycin 1/1,000,000
Ethambutol 1/100,000
Rifampin 1/100,000,000
INH
INH INH
RIF