Aromatase inhibitors (AIs),

No. Nama Zat aktif Indikasi Efek Samping

Obat

1. Arimidex Anastrozole Pengobatan kanker Hot flushes, kekeringan

payudara lanjut pada pada vagina, perdarahan
wanita post-menopause pada vagina, rambut
dengan reseptor estrogen tipis, anoreksia, mual,
positif dan atau reseptor muntah, diare, sakit
progesterone positif kepala, artalgia, retak
tulang, kemerahan
(termasuk sindrom
Stevens-Johnson),

HORMON astenia dan mengantuk

dapat menggangu
kemampuan

THERAPY mengendarai dan

menjalankan mesin,
dilaporkan terjadi sedikit
perubahan pada kadar
total kolesterol, sangat
jarang terjadi reaksi
alergi termasuk
angioedema dan
anafilaktik
No. Nama Obat Zat aktif Indikasi Efek Samping
2. Femara Letrozole Kanker payudara dengan hormone reseptor positif Astenia, edema perifer, kelelahan,
pireksia, peningkatan nafsu makan, rasa
haus, kekeringan, hot flush

3. Aromasin exemestane Exemestane is indicated for the treatment of Anorexia, depression, insomnia,
advanced breast cancer in women with natural or headache, dizziness, carpal tunnel
induced postmenopausal status whose disease has syndrome, somnolence, hot flushes,
progressed following anti-oestrogen therapy. Patient abdominal pain, nausea, vomiting,
selection should be based on positive oestrogen diarrhoea, constipation, dyspepsia,
and/or progesterone receptor status, because alopecia, rash, osteoporosis, pain,
efficacy has not been demonstrated when it is fatigue
absent.
 
Exemestane is indicated for the adjuvant treatment of
postmenopausal women with estrogen- receptor
positive early breast cancer, following 2-3 years of
initial adjuvant tamoxifen therapy.
 Selective estrogen receptor modulators (SERMs)

No. Nama Obat Zat aktif Indikasi Efek Samping

1. Tamofen dan Tamoxifen Tamoksifen Kanker payudara Hot flushes, perdarahan vagina dan
“Ebewe” vaginal discharge, supresi haid pada
wanita premenopouse pruritus vulva,
gangguan GI, tumor flare, nyeri kepala
ringan,

2. Evista raloxifene EVISTA is indicated for the treatment and prevention of Vasodilatation (hot flushes), Venous
osteoporosis in postmenopausal women. A significant thromboembolic events, including
reduction in the incidence of vertebral, but not hip deep vein thrombosis, pulmonary
fractures has been demonstrated. For those embolism, retinal vein thrombosis,
menopausal women taking EVISTA for osteoporosis superficial vein thrombophlebitis, Leg
treatment, EVISTA has been shown to reduce the risk of cramps , Flu syndrome, Peripheral
invasive breast cancer. oedema
When determining the choice of EVISTA or other
therapies, including oestrogens, for an individual
postmenopausal woman, consideration should be given
to menopausal symptoms, effects on uterine and breast
tissues, and cardiovascular risks and benefits.
 Estrogen receptor antagonists

No. Nama Zat aktif Indikasi Efek Samping

Obat

1. Faslodex Fulvestrant Treatment of The most frequently

postmenopausal women reported adverse
with estrogen receptor reactions are injection
positive, locally advanced site reactions,
or metastatic breast asthenia, nausea,
cancer for disease headache and
relapse on or after increased hepatic
adjuvant anti-estrogen enzymes (ALT, AST,
therapy or disease ALP)
progression on therapy
with an anti-estrogen.
 Luteinizing hormone-releasing hormone (LHRH) agonists
No. Nama Obat Zat aktif Indikasi
1. Zoladex Goserelin acetate • Prostate cancer : ZOLADEX
3.6 mg is indicated in the
management of prostate
cancer suitable for
hormonal manipulation
• Breaast cancer : ZOLADEX
is indicated In the
management of breast
cancer in premenopausal
and perimenopausal
women suitable for
hormonal manipulation.
• Endometriosis : In the
management of
endometriosis, ZOLADEX
alleviates symptoms,
including pain, and reduces
the size and number of
endometrial lesions.
Efek Samping
• Pada pria & wanita:
alergi (ruam, gatal,
pembengkakan, mapas
pendek, mengi), nyeri
perut, distensi perut,
napas pende, pusing,
tekana darah rendah,
hot flushes, penurunan
gairah seks, nyeri,
memar, pendarahan,
penipisan tulang,
kerontokan rambut,
penambahan berat
badan, nyeri pada sendi,
perubahan suasana hati
(termasuk depresi)
• Pada pasien pria saja :
Impotensi, nyeri pada
punggung bagian bawah
atau masalah buang air
kecil, nyeri tulang pada
awal
No. Nama Obat Zat aktif Indikasi
1. Zoladex Goserelin acetate • Prostate cancer : ZOLADEX
3.6 mg is indicated in the
management of prostate
cancer suitable for
hormonal manipulation
• Breaast cancer : ZOLADEX
is indicated In the
management of breast
cancer in premenopausal
and perimenopausal
women suitable for
hormonal manipulation.
• Endometriosis : In the
management of
endometriosis, ZOLADEX
alleviates symptoms,
including pain, and reduces
the size and number of
endometrial lesions.
Efek Samping
• Pada pria & wanita:
alergi (ruam, gatal,
pembengkakan, mapas
pendek, mengi), nyeri
perut, distensi perut,
napas pende, pusing,
tekana darah rendah,
hot flushes, penurunan
gairah seks, nyeri,
memar, pendarahan,
penipisan tulang,
kerontokan rambut,
penambahan berat
badan, nyeri pada sendi,
perubahan suasana hati
(termasuk depresi)
• Pada pasien pria saja :
Impotensi, nyeri pada
punggung bagian bawah
atau masalah buang air
kecil, nyeri tulang pada
awal
No. Nama Obat Zat aktif Indikasi Efek Samping
2 Zoladex LA Goserelin acetate • Prostate cancer : ZOLADEX LA is Pada pria & wanita: alergi
10.8 mg indicated in the management of (ruam, gatal,
prostate cancer suitable for hormonal pembengkakan, mapas
manipulation pendek, mengi), nyeri
• Premenopausal Breast Cancer : perut, distensi perut,
ZOLADEX LA is indicated in the napas pende, pusing,
management of premenopausal tekana darah rendah,
breast cancer for hormone receptor hot flushes, penurunan
positive. gairah seks, nyeri, memar,
• Endometriosis : ZOLADEX LA is pendarahan, penipisan
indicated in the management of tulang, kerontokan
endometriosis including alleviation of rambut, penambahan
symptoms such as pain. Experience berat badan, nyeri pada
with Zoladex LA for the management sendi, perubahan
of endometriosis has been limited to suasana hati (termasuk
women 18 years of age and older depresi)
treated for 6 months.
No. Nama Zat aktif Indikasi
Obat
2 Tapros Leuprorelin • Treatment of prostatic cancer with
acetate metastase
• Treatment of endometriosis at genital
and extragenital localization (from
stage I to stage IV). The clinical
knowledge concerning the
endometriosis treatment is limited to
women over 18 years old. The
treatment duration is limited to 6
months.
• Pre-operative management of uterine
myoma (fibroid) to reduce their size
and associated bleeding
• Treatment of central precocious
puberty
• Breast cancer in pre-menopausal and
peri-menopausal women, provided
endocrine treatment is indicated.
It is not recommended to start a second
treatment period with Tapros or with
another Gn-RH analogue.
Efek Samping
• Prostatic cancer : increase LDH,
jaundice, Hot flushes, feeling of
warmth, Headache, insomnia,
facial hot flushes, dizziness,
diaphoresis, decreased libido,
erectile dysfunction,
gynecomastia, testicular atrophy
or discomfort on the perineal
region, Arthralgia, bone pain, pain
in the shoulder, low back or limbs,
or difficulty in walking, stiffness of
fingers or other joints, dermatitis
or hair growth on the head,
pollakiuria, hematuria or increased
BUN, ECG abnormalities or
increased cardiothoracic ration,
anemia or platelet count
decreased, nausea, vomiting,
anorexia or constipation, rash or
pruritus, pain, induration and
redness, edema, pressure
sensation of chest, rigor
No. Nama Obat Zat aktif Indikasi Efek Samping
Pada pria & wanita: alergi
(ruam, gatal, pembengkakan,
mapas pendek, mengi), nyeri
perut, distensi perut, napas
pende, pusing, tekana darah
rendah, hot flushes,
penurunan gairah seks, nyeri,
memar, pendarahan,
penipisan tulang, kerontokan
rambut, penambahan berat
badan, nyeri pada sendi,
perubahan suasana hati
(termasuk depresi)
No. Nama Obat Zat aktif Indikasi Efek Samping
4. Eligard Leuprolin Eligard is indicated for the treatment of The most commonly
acetate hormone dependent advanced prostate reported adverse reactions
cancer are hot flashes, malaise,
nausea and fatigue and
transient local irritation at
the site of injection. Mild or
moderate hot flashes occur
in approximately 58% of
patients.

5. Pamorelin triptorelin •  The treatment of locally advanced or  Headache, libido derease,

metastatic, hormone sleep disorder, mood
dependent prostate cancer. altered, dyspareunia,
• As concomitant to and following radiot dysmenorrhea, genital
herapy in patients with high risk localiz hemorrhage, ovarian
ed or locally advanced prostate cancer. hyperstimulation syndrome,
• The treatment of endometriosis.  ovarian hypertrophy, pelvic
• The treatment of central precocious pu pain, abdominal pain,
berty (onset before 8 years in girls and  vulvovaginal dryness,
10 years in boys). hyperhidrosis, hot flushes,
asthenia, palpitations, QT
prolongation,
 Anti-androgens
No. Nama Obat Zat aktif Indikasi
1. Erleada apalutamide ERLEADA is indicated in adult men
for the treatment of non-distant
metastatic castration resistant
prostate cancer (nm-CRPC) who
are at high risk of developing
metastatic disease.
2 Casodex Bicalutamide Treatment of advanced prostate
cancer in combination with
luteinizing-hormone releasing
hormone (LHRH) analogue
therapy or surgical castration
Efek Samping
fatigue, skin rash, weight decreased,
arthralgia, and fall, hypothyroidism.
Anaemia, Hypersensitivity, angioedema and
urticaria, decreased appetite, decreased
libido, depression, dizziness, somnolence,
myocardial infarction, QT prolongation, hot
flush, interstitial lung disease, abdominal
pain, constipation, nausea, dyspepsia,
flatulence, hepatotoxicity, jaundice,
hypertransaminasaemia, alopecia, hirsutism,
dry skin, pruritus, rash, photosensitivity
reaction, haematuria, gynaecomastia and
breast, erectile dysfunction, asthenia,
oedema, chest pain, weight increased
No. Nama Obat Zat aktif Indikasi
3 Xtandi Enzalutamide • Xtandi in combination with
androgen deprivation therapy
is indicated for the treatment
of adult men with metastatic
castration-resistant prostate
cancer who are asymptomatic
or mildly symptomatic after
failure of androgen
deprivation therapy in whom
chemotherapy is not clinically
indicated
• Xtandi is indicated for the
second line treatment of adult
men with metastatic
castration-resistant prostate
cancer whose disease has
progressed on or after
docetaxel therapy.
Efek Samping
The most common adverse
reactions are asthenia/fatigue,
hot flush, fractures and
hypertension. Other
important adverse reactions
include fall, cognitive disorder,
and neutropenia.
Seizure occurred in 0.4% of
enzalutamide-treated
patients, 0.1% of placebo-
treated patients, and 0.3% in
bicalutamide-treated patients.
 CYP17 inhibitors
No. Nama Obat Zat aktif Indikasi
1 Zytiga ABIRATERONE Zytiga is indicated in
ACETATE combination with prednisone
for the treatment of metastatic
prostate cancer (castration-
resistant prostate cancer) in
patients who:
• Are asymptomatic or mildly
symptomatic after failure of
androgen deprivation
therapy (ADT) or
• Have received prior
chemotherapy containing
taxane
Zytiga in combination with
androgen deprivation therapy
(ADT) and prednisone or
prednisolone is indicated for the
treatment of adult men with
newly diagnosed metastatic
hormone-sensitive prostate
cancer (mHSPC)
Efek Samping
Urinary tract infection,
sepsis, adrenal insufficiency,
hypokalaemia,
hypertriglyceridaemia,
cardiac failure, angina
pectoris, atrial fibrillation,
tachyardia, hypertension,
allergic alveolitis, diarrhea,
dyspepsia, alaine
aminotransferase increased
and/or aspartate
aminotransferase increased,
hepatitis fulminant, acute
hepatic failure, rash,
myopathy, rhabdomyolysis,
hematuria, oedema
peripheral, fractures
 Luteinizing hormone-releasing hormone (LHRH) antagonists

No. Nama Obat Zat aktif Indikasi Efek Samping

1 Firmagon degarelix FIRMAGON® is a gonadotrophin hot flushes and

releasing hormone weight increase ,
(GnRH) antagonist  indicated for injection site
treatment of adult male patients with adverse events,
advanced hormone-dependent Transient chills,
prostate cancer.adult male patients fever or influenza
with advanced hormone-dependent like illness,
prostate cancer. anaemia, insomnia,
dizziness,
headache,
diarrhoea, nausea