Chicken infectious

anemia
Haemorrhagic syndrome
Blue wing
 Introduction
CIA is an acute viral infectious disease of
young chicken (less than 2 weeks)
Which is characterized by
 Aplastic anemia
 Lymphoid atrophy
 Hemorrhage under wings
 Severe immunosuppression leads to
secondary bacterial, viral or fungal
infections
 Etiology
 CIAV :Genus :Gyrovirus, Family
:Circoviridae
 Small(25 nm) spherical, non-enveloped
icosahedral virus
 contain a circular single-stranded DNA
genome.
 CAA was initially isolated in Japan.
(Yuasa et al )
 Inactivated by hypochlorite and formalin
The genome codes for 3 viral proteins (VP).
VP1
VP2
VP3 or apoptin
Distribution
Present worldwide
 Transmission
 Horizontal transmission; contact with
infected birds droppings, mechanical
vectors
 Vertical transmission; virus is shed into
eggs
 Clinical findings
 Subclinical infections leads to mortality (5-
10%) may go to 60% if inter-current disease
like IBD, IBH, Aspergillosis, poor
management (poor Litter)
 Anorexic, lethargic, depressed, and pale
 Characteristic subcutaneous hemorrhages
especially under wings
 Anemia, PCV is low 5-15% , leukopenia, or
pancytopenia.
 Pale bone marrow.
What is normal value of PCV in chicken ?
 Postmortem lesions
 Organs are pale;
 Thymus atrophy
 Pale or yellow Bone marrow
 Hemorrhage under the skin, muscle, and
other organs.
 Why hemorrhages under skin &
muscle?
 Histopathology
 Depletion of lymphoid cells in lymphoid
organs.
 Hematopoitic cells replaced by adipose
tissue & proliferating stroma cells
 Loss of demarcation between medulla and
cortex of bone marrow.
 Atrophy of bursal follicles
 Diagnosis
History
Clinical Signs,
Gross and Histopathological lesions.
PCR
ELISA
Virus isolation
 Treatment & control
 No specific treatment.
 Secondary bacterial infections may be
treated with antibiotics.
 Live vaccines are available for vaccination
of antibody-negative breeder flocks prior to
the start of egg production.
 Prevention
 Biosecurity
 Vaccination of breeders
What this picture is indicating?
Pale organs
S/C Hemorrhages
S/C Hemorrhages/ gangrenous
Dermatitis
Adipose tissue
Questions????