Serum uric acid level is associated with

reperfusion ventricular
arrhythmias in acute myocardial infarction
Shingo Watanabe*, Michio Usui
The Department of Cardiology, Tokyo Yamate Medical Center, 3-22-1 Hyakunincho, Shinjuku-
ward, Tokyo, 169-0063, Japan
 Introduction
In the acute phase of acute myocardial infarction (AMI), reperfusion
induced ventricular arrhythmias such as ventricular tachycardia and
ventricular fibrillation (Reperfusion VT/VF) resulting from reperfusion
injury are one of the causes of in-hospital death. Predicting Reperfusion
VT/VF is clinically important.
Previous studies have reported that oxidative stress is the cause of
reperfusion disorders and reperfusion arrhythmia. Another report,
reports that the production of free radicals caused by xanthine oxidase
(XO) is responsible for reperfusion arrhythmia. XO activity is enhanced
in hyperuricemia. We hypothesized that hyperuricemia is a risk factor
for reperfusion arrhythmias in acute myocardial infarction.
 The aim of this study is to investigate
whether serum uric acid is associated with
Reperfusion VT/VF in AMI.
 Method
This is a single-center, retrospective cohort study.

We enrolled 612 ST We divided patients We compared

.
elevation into a high serum thefrequency of
myocardial uric acid group Reperfusion VT/VF
infarction patients (HUA group) and a in both groups
who underwent low serum uric acid
successful primary group (LUA group)
percutaneous with a cutoff value
coronary of 7.0 mg/dl, which
intervention (PCI). is the standard value
of serum uric acid.
 Result

Creatinine tended to be higher in

There were 111 patients in the
the HUA group than in the LUA
HUA group and 512 patients in
group. (1.12 ± 0.41 mg/dl VS
the LUA group.
0.92 ± 1.10 mg/dl P ¼ 0.06).

The frequency of Reperfusion

VT/VF was significantly higher
in the HUA group than in the
LUA group (17.1% VS 4.0% P <
0.001)
 DISCUSSION
Our study showed that Serum uric acid was associated with Reperfusion VT/VF during the acute
phase of AMI. It is considered that acute ventricular arrhythmias are triggered in response to rapid
changes in oxidative status in the heart which are known to react with reactive oxygen species
(ROS) directly, and/ or indirectly as inhibitors of the free radical generating enzymes.
Past study showed that oxidative stress can induce events leading to various cellular defects upon
releasing several inflammatory agents, altered membrane permeability and configuration of proteins
 CONCLUSION
Elevated serum uric acid is associated with higher
frequency of reperfusion ventricular
arrhythmia.
Thankyou