P DRUGS

Roll no 35 to 44
You are working as a private practitioner in a village 20 km
from Theni with a population of 5,000 mostly farmers.

 Prepare your 'p’ list of drugs for hypertension

 Diagnosis : Hypertension
 Therapeutic objectives :
To treat the signs and symptoms
To prevent progression or recurrance
To reduce the load on the heart
To reduce cardiovascular morbidity and mortality
To lower the blood pressure
To prevent other systemic associated diseases such as acute kidney
injury.
MAKE AN INVENTORY OF EFFECTIVE GROUPS OF DRUGS :
. Drugs with anti hypertensive activity:

 1. Diuretics:: Thiazides: Hydrochlorothiazide.

 High ceiling:Furosemide.
 K+ Sparing: Spironolactone.
 2. ACE inhibitors:Captopril,Enalapril.
 3. Angiotensin (AT1 receptor) blockers : Losartan
 4. Calcium channel blockers :Amlodipine.
Choose an effective group according to
criteria
Groups Efficacy Safety Suitability Cost

+++ +++ +++ +

ACE inhibitors
Angiotensin +++ +++ +++ +++
receptor blockers
Calcium channel +++ + +++ +++
blockers
Diuretics +++ ++++ +++ +
Choose a P drug
Drugs Efficacy Safety Suitability Cost

Enalapril +++ +++ +++ +

Losartan +++ +++ +++ +++

Amlodipine +++ + +++ +++

Hydrochlorothiazide +++ ++++ +++ +

 The P drug of choice is Enalapril.

 In case if the person’s age is above 55 then drugs like calcium channel blockers and diuretics are
prescribed..since they have low renal activity
Thank you