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Definitions
Toxicology
science that deals with the poisonous or toxic
properties of substances;
most do not present a hazard under ordinary
circumstances, but they all have the potential
for being injurious at some sufficiently high
concentration and level of exposure
Toxic effect
any undesirable disturbances of
physiological function caused by poisons;
can also arise as side effects in response to
some medications, vaccines and exposure to
chemicals
Definitions
Toxicity
a physiological property of matter that defines
the capacity of a chemical to harm or injure a
living organism by other than mechanical
means;
it entails a definite dimension – quantity or
amount - and depends upon the degree of
exposure
Ability of a substance to produce an unwanted
effect when the chemical reached a sufficient
concentration at a certain site in the body
Hazard
The probability that concentration of toxics in
the body will occur
Threshold level
The level where the first effect or response to
a toxic substance is observed or detected
Contributing Factor to Determine the
Degree of Hazard of a Chemical
Ingestion
Injection
Skin absorption
Inhalation
Action of toxic substance
Acute toxicity
– Short-term exposure to a high concentration with
an immediate effect
Chronic toxicity
– Effects manifests over a period of time
Exposure
Concentration
Duration of exposure
Routes of entry
Individual susceptibility
Factors Affecting Human Susceptibility
Age
Sex
General health
Genetic variability
Anatomic variability
Nutrition
Previous exposure
Classification of Toxic Effect
Local
– When a certain chemical harms only the part of
the body it comes in contact with
Systemic
– When a certain chemical harms other related
organs operating as a system
Specific Organ Toxicity
Skin
Liver
Respiratory tract
Nervous system
Kidneys
Blood
Threshold Limit Values (TLVs)