Hemopoiesis

jai
 PHSC
 Bone marrow – PHSC
 PHSC – all cells in circulating blood

 PHSC – Reproduce, throughout life

 Small % remain – like original PHSC

 Retain in bone marrow – maintain

supply
 No diminishes with age
 Terminology
Committed stem cell

CFU - M
CFU - E CFU - GM
 Number & Distribution of blood
cells
 Total Erythrocytes –
5,000,000/cumm of blood
 Total leukocytes – 4000 –
11,000/cumm of blood
 Total platelets – 2,50,000/cumm of
blood
 Major Hemopoietic growth factors
 Erythropoietin - Erythrocytes
 Colony stimulating factors – G & M

 Interleukins – Various leukocytes

 Thrombopoietin – Platelets

 Stem cell factor – many blood cells