Botulinum Toxin Update

Lilik Norawati Ashadi

• A highly purified preparation of botulinum
toxin A produced by the bacterium
Clostridium botulinum.
• It acts by blocking the transmission of nerve
impulses to muscles and so paralyzes (relaxes)
the muscles.
Formulations
 Botox
The majority of peer-reviewed reports in the
literature focus on the original formulation of
BTX-A: Botox Cosmetic (Vistabel in most of
Europe and Vistabex in Italy)
 Dysport
• Dysport, is approved in over 65 countries,
differs from Botox in purification procedures
• There is some evidence that Dysport may
show greater diffusion and migration, with
increased potential for side effects and less
precise localization of clinical effects
 Xeomin
• In potency, Xeomin appears to exhibit a 1:1
dose ratio when compared with BOTOX, and
therapeutic clinical studies have found similar
levels of efficacy and safety
• Xeomin is free of complexing proteins, which
some believe may result in purer formulations
with greater efficacy and a reduced risk of
sensitization and antibody formation