KIMIA ORGANIK SINTESIS: part 2

Dr. Sc. SITI MARIYAH ULFA

 What is synthesis ?

Example:

Functional Group Interchange (FGI) = Interkonversi Gugus Fungsional (IGF)

 a process to change one functional group to another
 Transform vs Synthesis

Transform (Corey1): the exact reverse of a synthetic reaction to target structure

Target structure: final molecule is attempting to prepare
bond a is said to be disconnected
 Retrosynthesis

Retrosynthesis (Corey1): problem solving technique for transforming the structure of a

synthetic target molecule to a sequence of progressively simple materials a long a pathway
which ultimately leads to a simple or commercially available starting material for
chemical synthesis.
The Disconnection Approach
Polarizability of atoms

Seebach2) bond polarization model:

d : donor sites or nucleophilic atoms
a : acceptor sites or electrophilic atoms

Synton

Synthetic equivalent
Synthetic sequences for a and b
Typical organic reaction
Synthetic
equivalent for
selected
disconnect
products
Functional group exchange reaction wheel
 Activities 1: Synthesis Multistriatin
The synthesis of multistriatin  feromone of elm bark beetle
Synthesis Multistiarin
Synthesis Multistiarin
Summary