Comparison of Drugs

Submitted By: Shruti Dhalla

Submitted To : Dr. Abhishek Dhadhich
Course : MBA
 ANTI – DIABETIC DRUGS
JANUMET 50/500 mg
• Manufactured : MSD PHARMACEUTICAL
• Chemical entity : Metformin + Sitagliptin
• Pharmacology : Metformin is a Biguanide which acts by
suppressing hepatic Gluconeogenesis and enhances
insulin mediated glucose disposal. Sitagliptin is a DPPIV
inhibitor which inactivates incretins resulting in release
of insulin.
• Price : Rs. 380 per 15 tablets
GLYCOMET GP
• Manufacturer : GSV Pharmaceuticals
• Chemical Entity : Metformin + Glimeperide
• Pharmacology : Metformin acts by supressing hepatic
gluconeogenesis and increase glucose disposal whereas
Glimeperide is a sulfonylurea which binds tro receptor
SURI and helps release of Insulin
• Price : Rs 155 per 15 tablets
 CARDIOVASCULAR DRUGS
CARDACE
• Manufacturer : Sanofi India
• Chemical Entity : Ramipril
• Disease : Hypertension
• Pharmacology : Ramipril is an ACE Inhibitor which
lowers the production of Angiotensin II in the body
leading to decrease in the total peripheral resistance
therefore causing a decrease in Blood pressure.
• This may be prescribed for patients having Diabetes as
comorbidity
• Price : Rs 83 for 15 tablets.
AMDEPIN2.5
• Manufacturer : Cadila Pharmaceuticals Ltd.
• Chemical Entity : Amlodipine
• Disease : hypertension
• Pharmacology : Amlodipine belongs to class Calcium
Channel Blockers. It is an angiotensive calcium channel
blockers and inhibit passage of calcium ions into
vascular smooth muscles and cardiac muscles which
inhibits contraction of smooth muscles. This causes
reduction in peripheral resistance and thus the blod
pressure decreases.
• This is prescribed to patients having any comorbidities
except left ventrical dysfunction and congestive
cardiac failure.
• Price: Rs 27 per 15 tablets
 ANTI – HYPERLIPIDEMIC DRUGS
LIPITOR
• Manufacturer : Pfizer
• Chemical entity : Atorvastatin
• Therapeutic Class : HMG CoA reductase Inhibitor / Statin
• Pharmacology : They inhibit a specific enzyme HMG
CoA reductase which results in decreased production of
cholesterol. It specifically lowers LDL levels and
increase HDL levels in bloodstream
•  One of the most commonly prescribed statins in the
U.S. It is effective at reducing total cholesterol, LDL
cholesterol, and triglycerides. Lipitor also increases HDL
cholesterol.
• Price : $9.8 For 15 tablets
CRESTOR
• Manufacturer : Astra Zeneca
• Chemical entity : Rosuvastatin
• Therapeutic class : Statin
• Pharmacology : They inhibit a specific enzyme HMG CoA
reductase which results in decreased production of
cholesterol. It specifically lowers LDL levels and
increase HDL levels in bloodstream
• It causes significantly 
better reductions in total cholesterol at lower doses
compared to the other drugs in this class . It is available
in 5 mg, 10 mg, 20 mg, and 40 mg doses and is typically
taken once daily. 
• Price : Rs 388 for 10 tablets
 ANTI ASTHMATIC DRUGS
SINGULAIR ADVAIR

• Manufacturer : MSD Pharmaceuticals • Manufacturer : Glaxo Smith Kline

• Chemical entity : Montelukast • Chemical Entity : Salmetrol + Fluticasone
• Therapeutic Classification : Leukotriene receptor • Therapeutic classification : Beta blockers and
antagonist corticosteroid
• Pharmacology : It works by blocking the action of  • Pharmacology : Fluticasone is a synthetic corticosteroid
leukotriene D4 in the lungs resulting in decreased  that acts as a anti inflammatory agent. Salmeterol
inflammation and relaxation of smooth muscle. works by stimulating intracellular adenyl cyclase which
acts as a catalyst in the production of cyclic AMP.
Increased cyclic AMP levels lead to a relaxation of
bronchial smooth muscles. Additionally, cyclic AMP
inhibits the release of mediators of immediate
hypersensitivity.
• Price : $247 for 30 granules

• Price : $494 for inhaler and powder