Skin Cancers includes 3 types of Cancers

• Basal cell carcinoma -a type of skin cancer that most often

develops on areas of skin exposed to the sun, such as the face.

• Squamous cell carcinomas- is a common form of skin cancer

that develops in the squamous cells that make up the middle and
outer layers of the skin.

• Malignant melanoma- a common skin cancer that arises from

the melanin cells within the upper layer of the skin (epidermis) or
from similar cells that may be found in moles (nevi).
 Tissue of Origin

Basal cell carcinomas

Basal cell layer skin
These cells constantly divide to form new cells to replace the squamous cells
that wear off the skin's surface. As these cells move up in the epidermis, they
get flatter, eventually becoming squamous cells.
 Tissue of Origin
Squamous cell carcinomas
Squamous Epithelium
• The epidermis is a thin layer of squamous epithelial cells located on the
outermost surface of the skin. This layer is void of blood vessels or nerve
endings. The epidermis provides an excellent protective barrier when healthy
and intact. The stratum germinativum, or basal layer, is the parent layer for new
cells.
 Tissue of Origin

Malignant melanoma
Melanocytes
• It is specialized skin cell that produces the protective skin-darkening pigment
melanin.
 Tumor Type

Basal cell carcinoma is a type of skin cancer that most often

develops on areas of skin exposed to the sun, such as the
face. On brown and Black skin, basal cell carcinoma often
looks like a bump that's brown or glossy black and has a
rolled border.
Basal cell carcinoma appears as a change in the skin, such
as a growth or a sore that won't heal. These changes in the
skin (lesions) usually have one of the following
characteristics
 Tumor Type
Squamous cell carcinoma is a type of cancer. It develops
in squamous cells, which are the thin, flat cells that make up
the outermost layer of your skin. Squamous cells are also
found in other parts of your body such as your lungs,
mucous membranes, digestive tract, and urinary tract.
 Tumor Type

• Malignant Melanoma is a serious form of skin cancer that

begins in cells known as melanocytes.Melanoma is more
dangerous because of its ability to spread to other organs
more rapidly if it is not treated at an early stage.
• malignant melanoma is a neoplasm of melanocytes or a
neoplasm of the cells that develop from melanocytes.
 Tumor Growth
• Basal cell carcinoma usually grows very slowly and often doesn't
show up for many years after intense or long-term exposure to the
sun.
• Squamous cell carcinomas is Rapidly growing SCC occurred most
commonly on the head and neck, followed by hands and
extremities, and had an average duration of 7 weeks before
diagnosis.
• Malignant melanoma- One third of the melanomas grew 0.5 mm
per month or more. The median monthly growth rate was 0.12 mm
for superficial spreading melanomas, 0.13 mm for lentigo maligna
melanomas, and 0.49 mm for nodular melanomas.
References
• https://www.healthline.com/health/squamous-cell-skin-cancer
• https://www.mayoclinic.org/diseases-conditions/basal-cell-carcinoma/symptoms-causes/syc-
20354187#:~:text=Basal%20cell%20carcinoma%20is%20a%20type%20of%20skin
%20cancer.,it%20can%20take%20other%20forms.