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    raghavendra praneeth
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    This document summarizes key details of four PDE5 inhibitor drugs used to treat erectile dysfunction: sildenafil (Viagra), vardenafil (Levitra), tadalafil (Cialis), and avanafil (Stendra). It provides information on their innovator companies, approval status, indications, dosages, dosage forms, efficacy rates, safety profiles, and whether they have been approved in combinations.

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    This document summarizes key details of four PDE5 inhibitor drugs used to treat erectile dysfunction: sildenafil (Viagra), vardenafil (Levitra), tadalafil (Cialis), and avanafil (Stendra). It provides information on their innovator companies, approval status, indications, dosages, dosage forms, efficacy rates, safety profiles, and whether they have been approved in combinations.

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    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
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    6 views1 page

    PDE

    Uploaded by

    raghavendra praneeth
    This document summarizes key details of four PDE5 inhibitor drugs used to treat erectile dysfunction: sildenafil (Viagra), vardenafil (Levitra), tadalafil (Cialis), and avanafil (Stendra). It provides information on their innovator companies, approval status, indications, dosages, dosage forms, efficacy rates, safety profiles, and whether they have been approved in combinations.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
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    of 1

    Sildenafil Vardenafil Tadalafil Avanafil

    Innovator & Pfizer(Viagra, Revatio) GSK(Levitra , Staxyn) Eli Lilly(Cialis, Adcirca) Mitsubishi Tanabe Pharma
    Brand Name ( Stendra)

    Approval status FDA-1996 FDA-2003 FDA 2003 FDA 2012


    EMA-1998 EMA-2005 EMA-2002 EMA 2013
    DCGI-2000 approved but DCGI-2018 DCGI-2017 DCGI-2021
    rejected by company
    Indication PAH(Revatio) Erectile Dysfunction PAH(Adcirca) Erectile Dysfunction
    Erectile Dysfunction (Viagra) Erectile Dysfunction(Cialis)

    Dose 50 mg taken approximately 30 10mg ; 5mg( for Men 65years old 10mg (when used as needed) 100 mg taken
    minutes before sexual activity and above) 60 minutes before sexual 2.5mg (when used daily) 30minutes approximately 30 minutes
    activity before sexual activity before sexual activity

    Dosage forms Tablets 25mg/50mg/100mg Tablets 5mg/10mg/20mg Tablets 2.5mg/5mg/10mg/20mg Tablets


    Oral suspension, Injection forms Staxyn dissolves under tongue 50mg/100mg/200mg

    Efficacy 77% 57-82% 70% 60-80%

    Safety highest chance of priapism More chance of priapism More chance of priapism Less Chance of priapism

    CV Safety study NA NA NA NA

    Approved NIL NIL NIL NIL


    combinations
    1

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