Respiratory System

• Gas exchange
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• Why do we breathe? Think of all the T

reasons why we need a respiratory O
system. G
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 Warning: terminology!
• “Respiration” is used several different ways:
• Cellular respiration is the aerobic breakdown
of glucose in the mitochondria to make ATP.
• Respiratory systems are the organs in animals
that exchange gases with the environment.
• “Respiration” is an everyday term that is
often used to mean “breathing.”
Respiratory system function

• Respiratory systems allow animals to

move oxygen (needed for cellular
respiration) into body tissues and
remove carbon dioxide (waste product
of cellular respiration) from cells.
 Gas exchange by Diffusion

• Some animals simply

allow gases to diffuse
through their skins.
• These animals have a
low metabolic rate.
Why?
• All of these are aquatic
animals. Why?
 Specialized structures
• Structures
specialized for gas
exchange include:

• gills (aquatic
animals)

• spiracles
(terrestrial insects)

• lungs (most
terrestrial
vertebrates)
 Countercurrent Exchange
• In a concurrent
system, exchange is
inefficient.
Equilibrium is
reached at one end.

• In a countercurrent
system, equilibrium
is not reached, so gas
exchange continues,
increasing efficiency.
 Fish Gills
• Fish increase gas
exchange efficiency
using countercurrent
exchange.

• Running blood through

the system in the
opposite direction to
water keeps a diffusion
gradient throughout
the entire exchange.
Gills exchange gases in fish. What is the site of
gas exchange in mammals?
25% 25% 25% 25%

1. Alveoli
2. Tracheids
3. Bronchi
4. Esophagus

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• Why are gills so widely seen in aquatic K
animals but not in land animals?
T
• One group of land animals that have O
gills is the Isopods (“pill bugs” and “sow G
bugs”). How can these organisms E
T
survive on land with gills?
H
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Human respiratory system
• Parts of the
respiratory system
include:

• Trachea

• Bronchi

• Bronchioles

• Alveoli
 Moving air in and out
• During inspiration
(inhalation), the
diaphragm and
intercostal muscles
contract.

• During exhalation,
these muscles relax.
The diaphragm
domes upwards.
 Alveoli
• The alveoli are
moist, thin-walled
pockets which are
the site of gas
exchange.

• A slightly oily
surfactant prevents
the alveolar walls
from collapsing and
sticking together.
 Circulation and Gas Exchange
• Recall the
interconnection
between circulation
and the respiratory
system.

• Gas exchange at the

lungs and in the
body cells moves
oxygen into cells
and carbon dioxide
out.
What happens when you breathe in?
1. The rib muscles 25% 25% 25% 25%
relax.
2. The diaphragm
contracts.
3. Air leaves the
alveoli.
4. Air moves between
the chest wall and
the lung.
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 W
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• Premature infants sometimes die of lung T
collapse and other lung problems. What O
might preemies be missing? How could G
this be remedied? E
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 In the alveolus
• The respiratory
surface is made up
of the alveoli and
capillary walls.

• The walls of the

capillaries and the
alveoli may share
the same
membrane.
 Gas exchange
• Air entering the lungs
contains more oxygen
and less carbon dioxide
than the blood that
flows in the pulmonary
capillaries.

• How do these
differences in
concentrations assist
gas exchange?
 Oxygen transport

• Hemoglobin binds
to oxygen that
diffuses into the
blood stream.

• What are some

advantages to using
hemoglobin to
transport oxygen?
 Carbon dioxide transport
• Carbon dioxide can
dissolve in plasma,
and about 70%
forms bicarbonate
ions.

• Some carbon
dioxide can bind to
hemoglobin for
transport.
 At the cells
• Cells use up oxygen quickly for cellular
respiration. What does this do to the
diffusion gradient? How does this help
cells take up oxygen?
• Cells create carbon dioxide during
cellular respiration, so CO2 levels in the
cell are higher than in the blood coming
to them. How does this help cells get rid
of oxygen?
Diffusion of O2 from lungs to blood is
rapid because:
1. Active transport 33% 33% 33%
moves oxygen.
2. Hemoglobin takes
up oxygen, keeping
plasma
concentration low.
3. Blood plasma is
oxygen-rich.

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Most of the oxygen in blood is:
25% 25% 25% 25%
1. In the white cells.
2. Bound to
hemoglobin.
3. Combined with
carbon to make
carbon dioxide.
4. Dissolved in the
plasma.

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 Effects of smoking
Gross, isn’t it?
• Inhaled smoke contains:

• CO2, which affects the

CO2 diffusion gradient.

• carcinogenic chemicals
that can trigger tumors.

• toxic nicotine, which

paralyzes cilia that
normally clean the
lungs.
 Emphysema
• Besides cancer, smoking
can also lead to
emphysema. Alveoli
become dry and brittle,
and eventually rupture.

• Both active and passive

smoking (“second-
hand” smoke) can lead
to can lead to lung All types of smoke, not just tobacco, can
problems. cause cancers and emphysema.
 Cystic Fibrosis
• Cystic fibrosis is one of
the most common
inherited disorders in
the Caucasian
population in the U.S.

• CF is caused by
mutation of a single
gene, the CFTR gene,
which controls salt
balance in the lungs.
 Cystic Fibrosis
• A normal CFTR protein
regulates the amount of
chloride ions across the
cell membrane of lung
cells.

• If the interior of the cell

is too salty, water is
drawn from lung mucus
by osmosis, causing the
mucus to become thick
and sticky.
 Cystic Fibrosis
• At this point there is no
cure for CF, though
there are therapies that
have extended the lives
of CF patients, including
lung transplants.

• Gene therapy may one

day insert “good” CFTR
genes into lung cells to
make them operate
normally.
“Two lies and a truth” – which one is
true?
1. Cigarette smoke cures 33% 33% 33%
colds because it kills
bacteria in the lungs.
2. Nicotine is one of the
most potent
neurotoxins on earth.
3. “Passive” smoking is
less harmful than
“regular” smoking.

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• When people quit smoking, if the lungs
K
are not damaged they can often clean
themselves because the cilia are no T
longer paralyzed. People with cystic O
fibrosis have trouble with lung infections G
because their lung mucus is thick and E
sticky. What roles do cilia and mucus T
play in lung health? H
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