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“GRAFT VERSUS
HOST DISEASE”
(GVHD)
PRESENTED BY: IQRA FARHAD
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WHAT IS GVHD?
Graft-versus-host disease (GVHD) is an
immune condition that occurs in a
patient after transplantation when
immune cells present in donor tissue
(the graft) attack the host's own tissues.
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OVERVIEW:
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TYPES OF GVHD
ACUTE:
It usually occurs within the first 100
days after the transplant

CHRONIC:
It usually occurs at about three
months post-transplant.
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HOW GVHD IS CAUSED?

DONOR PATIENTS’ IMMUNOCO

T-CELLS IMMUNE MPROMISE
CELLS D
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HOW IT OCCURS?
IN ACUTE:
1. CONDITIONING ( TISSUE DAMAGE)
2. ANTIGEN PRESENTING CELLS (APC)
ACTIVATED
3. DONOR T CELL RECOGNIZE APC
4. INFLAMMATORY CASCADE RESULTS
IN HELPER T –CELLS ACTIVATION
5. TH1 CD4 + CD8 + CYTOTOXIC
CELL ACTIVITY
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CONT..
IN CHRONIC:
1. T-CELLS ACTIVATION IN RESPONSE
TO ALLOANTIGENS
2. INFLAMMATORY CYTOKINES
PROCEEDS TO FICBROSIS
3. B-CELLS ACTIVATION
4. PRODUCTION OF AUTOANTIBODIES
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RISK FACTORS:
HLA DISPARITY
UNRELATED DONORS
OLDER DONOR AND RECIPIENT
SEX MISMATCH
STEM CELL SOURCE
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PATIENT:

SUSAN MITCHELLE
“A BONE MARROW
TRANSPLANT PATIENT”
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SYMPTOMS:
 RASH,ITCHING,REDNESS OF SKIN
 DARK SPOTS
 JAUNDICE
 ABNORMAL LIVER TESTS
 DRY AND BURNING EYS
 BACTERIAL INFECTIONS
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LESS COMMON:

SEVERE LIVER DISEASES

SKIN SCARRING
HEART BURN,STOMACH PAIN
DIFFICULTY SWALLOWING
BRONCHITIS,PNEUMONIA
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DIAGNOSIS:
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TREATMENT:
More precise HLA tissue matching
Immunosuppressive drugs
Depletion of T lymphocytes from the
donor graft
The use of umbilical cord blood as the
source of donor cells
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SUPPORTIVE CARE:
NUTRITION
DRUGS
SUPPORTIVE CARE MEASUERS
FOR SKIN,MOUTH ETC
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