Antiscabious and antipedicular agents

Scabicides ( antiscabious agents) are compounds used to control

the mite sarcoptes scabiei, an organism that thrives under
condition of poor personal hygiene or
Those agent used to control the
mites infection under condition of poor personal hygiene.
eg: Benzyl benzoate
Pediculocides (antipedicular agents) are used to treat lice
infection.
An ideal scabicides and pediculocides must kill the adult
parasites and destroy their eggs.
eg: permethrin, GBHC( Gama benzene hexachloride)
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Benzyl benzoate
Chemistry:
• It is an ester of benzoic acid
• It is formed by esterification
reaction between benzoic acid and
benzyl alcohol.
Physical properties:
• It is colorless liquid with a faint
aromatic odour
• It is insoluble in water but soluble
in organic solvent
• It is non staning and non irritating
to skin.
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Uses:
• it is use to treat lice infestation and scabies.
• It is used as organic solvent in industries.
• Give immediate relief from itching
• It effective scabicide when applied topically.
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GBHC (Gama benzene
hexachloride/ lindane/Benzene
hexachloride)
Chemistry:
• It has cyclohexane ring
• Six chlorine atom are attached
on each corner and called
benzene hexachloride.
• It is stable under acidic or
neutral condition but
undergoes elimination reaction
under alkaline condition.
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Uses:
• To treat lice infestation and scabies.
• It can used as an insecticide in agriculture.
• It is also use in skin disease like fungal infection allergic
reaction etc.
• Use locally as cream, lotion, shampoo for the treatment of
scabies and pediculosis.
• Its effects on insects is similar to that of DDT
(Dichlorodiphentrichloroethane)
• Its toxicity is lower than DDT