ACE

INHIBITOR
S
 ACE INHIBITORS
Angiotensin Converting Enzyme Inhibitors

Angiotensin II
 One of the most critical
hormones in renin-angiotensin-
aldosterone system.
 Regulate blood pressure in
our body.

Class of ACE inhibitors

Act on ACE → lower blood
vessel resistance → decrease
blood pressure.
ACE
DRUGS
SIDE EFFECTS
 CENTRAL
ADRENERGI
C
INHIBITORS
 CENTRAL ADRENERGIC
INHIBITORS
Central-acting agents/Central alpha agonists

Stimulate α-2 receptors →

reduce sympathetic outflow
→ decrease:
 total peripheral resistance
 renal vascular resistance
 heart rate & stroke volume
 blood pressure

Note: Prescribed in combination with other drugs.

 CENTRAL
ADRENERGI
C
INHIBITORS
EXAMPLES
 SIDE
EFFECTS