ERITROCITOPATÍAS

Mg. Angel Augusto Pérez Valverde

POLYCYTHEMIA
POLYCYTHEMIA
ABSOLUTE POLYCYTHEMIA: PRIMARY
ABSOLUTE POLYCYTHEMIA: SECONDARY
ABSOLUTE POLYCYTHEMIA: SECONDARY
PRIMARY POLYCYTHEMIA: ETIOLOGY
PRIMARY POLYCYTHEMIA:
LABORATORY
PRIMARY POLYCYTHEMIA:
LABORATORY
PRIMARY POLYCYTHEMIA:
LABORATORY
PRIMARY POLYCYTHEMIA:
SYMPTOMS AND SYGNS
PRIMARY POLYCYTHEMIA:
SYMPTOMS AND SYGNS
PRIMARY POLYCYTHEMIA:
SYMPTOMS AND SYGNS
PRIMARY POLYCYTHEMIA:
TREATMENT
RELATIVE POLYCYTHEMIA: SPURIOUS
OR PSEUDOPOLYCYTHEMIA
ANEMIA
IRON DEFICIENCY ANEMIA
1. ETIOLOGY
IRON DEFICIENCY ANEMIA
2. SIGNS AND SIMPTOMS
SYNTOMAS
• Fatiga
• Debilidad
• Mareo
• Cefalea
• Tinitus
SIGNOS
-Palidez
-Pica
-Sindrome de Plummer-Vinson (Adherencias esofágicas, Disfagia)
-Intolerancia al ejercicio
-Taquipnea
-Taquicardia
IRON DEFICIENCY ANEMIA
3. LABORATORY
• Microcítica, hipocrómica
• Fe low
• Hb low
• Hct low
• MCV low
• Ferritin <30 mcg/L
• Biopsia de médula ósea y tinción con azul de Prusia
que muestran ausencia de las reservas de Fe
Hb, MCV and ferritin
• Low Hb
• In men aged over 15 years — Hb below 130 g/L.
• In women aged over 15 years — Hb below 120 g/L.
• In children aged 12–14 years of age — Hb below 120 g/L.
• Low mean cell volume (MCV):
• In adults, microcytosis is when the MCV is less than 80 femtolitres
Serum ferritin level of less than 15 micrograms/L confirms the diagnosis of
iron deficiency.  
IRON DEFICIENCY ANEMIA
1. TREATMENT
PERNICIOUS ANEMIA
1.ETIOLOGY
 PERNICIOUS ANEMIA
2.SIGNS AND SYMPTOMS
PERNICIOUS ANEMIA
3. LABORATORY
Haemoglobin concentration Normal values: F = 11.5 – 16.5g/dl,
M=13-18g/dl

Macrocytosis

B12 levels (with caution – active and inactive levels are measured
but only active ‘work’)

Folate (often reduced in B12 deficiency)

Haematocrit – level shows quantity of blood containing red cells.

Low level indicates anaemia
PERNICIOUS ANEMIA
4. TREATMENT
 APLASTIC ANEMIA
1. ETIOLOGY
• The most
common cause of aplastic
anemia is from your immune
system attacking the stem cells
in your bone marrow. Other
factors that can injure bone
marrow and affect blood cell
production include: Radiation
and chemotherapy treatments
FANCONI ANEMIA
• AML: Scute
Myeloid
Leukemia
 APLASTIC ANEMIA
2.SIGNS AND SYMPTOMS
 APLASTIC ANEMIA
3.LABORATORY

• Pancytopenia with hypo-

Cellullarity (Aplasia) Bone
Marrow
APLASTIC ANEMIA
4. TREATMENT
THALASSEMIA
1. ETIOLOGY
 THALASSEMIA
2. SIGNS AND SYMPTOMS
 THALASSEMIA
3. LABORATORY
THALASSEMIA
4. TREATMENT
SICKLE CELL ANEMIA
1. ETIOLOGY
 SICKLE CELL ANEMIA
2. SIGNS AND SYMPTOMS
SICKLE CELL ANEMIA
3. LABORATORY
SICKLE CELL ANEMIA
4. TREATMENT
OTRAS
SPHEROCYTOSIS
SPHEROCYTOSIS
ELLIPTOCYTOSIS
SPHEROCYTOSIS
STOMATOCYTOSIS
PAROXYSMAL NOCTURNAL
HEMOGLOBINURIA
PAROXYSMAL NOCTURNAL
HEMOGLOBINURIA
PAROXYSMAL NOCTURNAL
HEMOGLOBINURIA
PYRUVATE KINASE
DEFICIENCY
G6PD DEFICIENCY
G6PD DEFICIENCY
G6PD DEFICIENCY
G6PD DEFICIENCY
G6PD DEFICIENCY
HEMOLYTIC ANEMIA
ETIOLOGY
IMMUNE
IMMUNE HEMOLYTIC ANEMIA
1. ETIOLOGY
AUTOIMMUNE (AIHA)
AUTOIMMUNE (AIHA)
ALLOIMMUNE
•HEMOLYTIC DISEASE OF
THE NEWBORN
ERYTRHROBLASTOSI
ERYTRHROBLASTOSIS FETALIS
ERYTRHROBLASTOSIS FETALIS
ERYTRHROBLASTOSIS FETALIS
ERYTRHROBLASTOSIS FETALIS
ERYTRHROBLASTOSIS FETALIS
ALLOIMMUNE:
•HEMOLYTIC
TRANSFUSION
REACTION
DRUG-RELATED
NOINMMUNE
HEMOLYTIC UREMIC
SYNDROME (HUS)
HEMOLYTIC UREMIC
SYNDROME (HUS)
PARASITIZATION OF RBC