PATHOPHYSIOLOG

1
Y
 NON-MODIFIABLE FACTOR
● Female
● Family Hx of Breast Cancer

DNA damage and failure of DNA repair

Genome of somatic cell mutations

Activation of growth promoting Inactivation of tumor suppressor Alteration in the genes

genes (BRCA 1, BRCA 2) regulating apoptosis (p53)
oncogenes

Unregulated cell proliferation Decreased apoptosis

 Clonal expansion

- Mammogram: abnormalities in
the right breast but no palpable
masses on breast examination Tumor progression
-Mammographically localized
excisional biopsies:
● Both areas and both
lesion were shown to
be malignant
● RUOQ: grade III
Cell proliferation Malignant Cell proliferation in the Infiltrating ductal
in the ducts of the neoplasm ducts of the left breast cancer of left breast
infiltrating ductal
right breast
carcinoma measuring
0.9 cm with clear
margins
● RLOQ: ductal
carcinoma in situ
(DCIS) measuring 0.6
cm in greatest

BREAST CANCER
diameter but with
positive margins

- (-) estrogen and

progesterone receptors