Growth Hormone

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Growth Hormone
 Growth Hormone

Growth hormone (GH) or somatotropin, also known as human growth hormones (hGH or HGH) in its

human form, is a peptide hormone that stimulates growth, cell reproduction, and cell regeneration in humans
and other animals. It is thus important in human development. GH also stimulates production of IGF-1 and
increases the concentration of glucose and free fatty acids. It is a type of mitogen which is specific only to
the receptors on certain types of cells. GH is a 191-amino acid, single-chain polypeptide that is synthesized,
stored and secreted by somatotropic cells within the lateral wings of the anterior pituitary gland.
 Growth Hormone

Nomenclature
The names somatotropin (STH) or somatotropic hormone refer to the growth hormone produced naturally in
animals and extracted from carcasses. Hormone extracted from human cadavers is abbreviated hGH. The main
growth hormone produced by recombinant DNA technology has the approved generic name (INN
) somatropin and the brand name Humatrope, and is properly abbreviated rhGH in the scientific literature.
Since its introduction in 1992 Humatrope has been a banned sports doping agent,  and in this context is
referred to as HGH.
 Growth Hormone

Growth hormone (GH), also called somatotropin or human growth hormone, peptide hormone secreted by the

anterior lobe of the pituitary gland. It stimulates the growth of essentially all tissues of the body, including bone
. GH is synthesized and secreted by anterior pituitary cells called somatotrophs, which release between one and
two milligrams of the hormone each day. GH is vital for normal physical growth in children; its levels rise
progressively during childhood and peak during the growth spurt that occurs in puberty.
 Growth Hormone

In biochemical terms, GH stimulates protein synthesis and increases fat breakdown to provide the energy

necessary for tissue growth. It also antagonizes (opposes) the action of insulin. GH may act directly on
tissues, but much of its effect is mediated by stimulation of the liver and other tissues to produce and
release insulin-like growth factors, primarily insulin-like growth factor 1 (IGF-1; formerly called
somatomedin). The term insulin-like growth factor is derived from the ability of high concentrations of
these factors to mimic the action of insulin, although their primary action is to stimulate growth. Serum
IGF-1 concentrations increase progressively with age in children, with an accelerated increase at the time
of the pubertal growth spurt. After puberty the concentrations of IGF-1 gradually decrease with age, as do
GH concentrations.
 Growth Hormone

GH secretion is stimulated by growth hormone-releasing hormone (GHRH) and is inhibited by somatostatin. In

addition, GH secretion is pulsatile, with surges in secretion occurring after the onset of deep sleep that are especially
prominent at the time of puberty. In normal subjects, GH secretion increases in response to decreased food intake
and to physiological stresses and decreases in response to food ingestion. However, some individuals are affected by
abnormalities in GH secretion, which involve either deficiency or overabundance of the hormone.
 Growth Hormone Deficiency

GH deficiency is one of the many causes of short stature and dwarfism. It results primarily from damage to
the hypothalamus or to the pituitary gland during fetal development (congenital GH deficiency) or
following birth (acquired GH deficiency). GH deficiency may also be caused by mutations in genes that
regulate its synthesis and secretion. Affected genes include PIT-1 (pituitary-specific transcription factor-1)
and POUF-1 (prophet of PIT-1). Mutations in these genes may also cause decreased synthesis and
secretion of other pituitary hormones. In some cases, GH deficiency is the result of GHRH deficiency, in
which case GH secretion may be stimulated by infusion of GHRH. In other cases, the somatotrophs
themselves are incapable of producing GH, or the hormone itself is structurally abnormal and has little
growth-promoting activity. In addition, short stature and GH deficiency are often found in children
diagnosed with psychosocial dwarfism, which results from severe emotional deprivation. When children
with this disorder are removed from the stressing, nonnurturing environment, their endocrine function and
growth rate normalize.
Children with isolated GH deficiency are normal in size at birth, but growth retardation becomes evident
within the first two years of life. Radiographs (X-ray films) of the epiphyses (the growing ends) of bones
show growth retardation in relation to the patient’s chronological age. Although puberty is often delayed, 
fertility and delivery of normal children is possible in affected women.
 Growth Hormone Deficiency
GH deficiency is most often treated with injections of GH. For decades, however,
availability of the hormone was limited, because it was obtained solely from human
cadaver pituitaries. In 1985, use of natural GH was halted in the United States and
several other countries because of the possibility that the hormone was
contaminated with a type of pathogenic agent known as a prion, which causes a
fatal condition called Creutzfeldt-Jakob disease. That same year, by means of 
recombinant DNA technology, scientists were able to produce a biosynthetic
human form, which they called somatrem, thus assuring a virtually unlimited
supply of this once precious substance.
Children with GH deficiency respond well to injections of recombinant GH, often
achieving near-normal height. However, some children, primarily those with the
hereditary inability to synthesize GH, develop antibodies in response to injections
of the hormone. Children with short stature not associated with GH deficiency may
also grow in response to hormone injections, although large doses are often
required.
 Growth Hormone Deficiency

A rare form of short stature is caused by an inherited

insensitivity to the action of GH. This disorder is known
as Laron dwarfism and is characterized by abnormal GH 
receptors, resulting in decreased GH-stimulated production of
IGF-1 and poor growth. Serum GH concentrations are high
because of the absence of the inhibitory action of IGF-1 on GH
secretion. Dwarfism may also be caused by insensitivity of bone
tissue and other tissues to IGF-1, resulting from decreased
function of IGF-1 receptors.
GH deficiency often persists into adulthood, although some
people affected in childhood have normal GH secretion in
adulthood. GH deficiency in adults is associated with fatigue,
decreased energy, depressed mood, decreased muscle strength,
decreased muscle mass, thin and dry skin, increased 
adipose tissue, and decreased bone density. Treatment with GH
reverses some of these abnormalities but can cause fluid
retention, diabetes mellitus, and high blood pressure (
hypertension).
 Recombinant Growth Hormone

A recombinant form of hGH called somatreopleopin (INN) is used as a prescription drug to treat children's growth

disorders and adult growth hormone deficiency. it is only available legally from pharmacies by prescription from a
licensed health care provider. In recent years, some health care providers are prescribing growth hormone in the
elderly to increase vitality. recombinant HGH is a pleiotropic cytokine of the hematopoietic growth factor
superfamily, which encompasses most cytokines, hematopoietic growth factors, and related receptors, and
includes the related growth hormone receptor, prolactin, placental lactogens, proliferins, and somatolactin (SST).
GH is primarily recognized for its anabolic role in stimulating the growth and differentiation of muscle, bone, and
cartilage. A number of other functions, including immunomodulatory actions, are also attributed to GH, due in
part to the pervasive distribution of its receptors, and the indirect effects associated with GH-stimulated
production of insulin-like growth factors (IGFs). Occurring predominantly in the somatotropes of the anterior
pituitary, whereupon it is stored in secretory granules, production of GH has also been noted in many other tissues,
including those of the hematopoietic system. The production and pulsatile release of circulating GH is very tightly
regulated by both negative and positive feedback regulations of pituitary and hypothalamic hormones, such as
Pituitary-specific Positive Transcription Factor 1 (POU1F1), Growth Hormone Releasing Hormone (GHRH), and
somatostatin (SRIF). Deficient production of GH is associated with dwarfism and reduction of lean body mass,
while overproduction is associated with acromegaly and gigantism, as well as breast tumor growth. Recombinant
Human Growth Hormone is a 22.3 kDa, single, non-glycosylated polypeptide chain containing 192 amino acid
residues. The source is E.coli most often.
 GHR (Growth Hormone Releaser) - Pro Life

Taller, stronger, faster

Prolife’s GHR (amino acid blend) is a special combination of amino acids and
Colostrum, important for growth and development in children.
This GHR is specifically designed for children.
GHR is a Growth Hormone Releaser is a hormone that is released to help stimulate
growth and cell reproduction in humans.
Claimed to be beneficial for children to:
•Grow Taller
•Strengthen hair, nails and bones
•Supply all their nutritional needs
•Increase Brain Function and Memory
 GHR (Growth Hormone Releaser) - Pro Life
• Amino acids are the building blocks for protein. Protein supports muscle
development in active children.
• The amino acids in this formula provide nutrition to support growth hormone
release.
• L-Tryptophan maintains mood in children by supporting neurotransmitter
production.
• Calcium is essential in children’s diets to support new bone production and
maintenance.

Ingredients
Each tablet contains: L-Arginine 75mg, L-Histidine 25mg, Calcium (Chelate) 5mg,
L-Tryptophan 5mg. This product contains tableting aids.

Suggested Use
Children (age 3-7): Take 1 tablet twice daily. Children (age 8+): Take 2-3 tablets
twice daily. Take 30 minutes before food and prior to bedtime, or as professionally
recommended. Care needs to be taken when given to younger children and ADULT
SUPERVISION IS REQUIRED. The tablets are easy to swallow but can be crushed
and mixed with food, such as yoghurt.
 GHR (Growth Hormone Releaser) - Pro Life

• Pro-life GHR is a form of human growth hormone important for the growth of
bones and muscles.
• Pro-life GHR is used to treat growth failure in children and adults who lack natural
growth hormone. This includes kids with short stature due to Noonan syndrome,
Turner syndrome, Prader-Willi syndrome, short stature at birth with no catch-up
growth, and other causes. 
 GHR (Growth Hormone Releaser) - Pro Life

• No red list ingredients • Respect

• No harmful chemicals • Honesty
• No environmental pollutants • Ethical integrity
• No surprise sugar
GHR (Growth Hormone Releaser) - Pro Life