Anatomy refers to the internal and external structures of the body and their physical relationships, whereas physiology refers to the study of the functions of those structures. This chapter defines anatomy and physiology and explains why they are important to biomedical engineering. Human bodies are divided into two main regions, axial and appendicular. The axial part consists of the head, neck, thorax, abdomen, and pelvis whereas the appendicular part consists of the upper and lower extremities. The upper extremities include the shoulders, upper arms, forearms, wrists, and hands whereas the lower extremities include the hips, thighs, lower legs, ankles, and feet. The abdominal region can be further divided into nine regions or four quadrants. Furthermore, cell theory, the major types of organic compounds and other elements found in cells, and how the plasma membrane maintains the volume and internal concentrations of a cell has been discussed. • covers a broad range of topics, including strength of biological materials, biofluid mechanics in the cardiovascular and respiratory systems, material properties and interactions of medical implants and the body, heat and mass transfer into biological tissues, biocontrol systems regulating metabolism or voluntary motion, and kinematics and kinetics applied to study human gait. Furthermore, the chapter provides a review of concepts from introductory statics and dynamics and presents concepts from mechanics of material that are fundamental for engineers and accessible to those with only a statics or dynamics background. The chapter introduces visco-elastic complexities characteristic of biological materials, with the concepts further applied in cartilage, ligament, tendon, and muscle. The last two sections of the chapter bring all of this information together in two ‘‘real world’’ biomechanics