PRIMARY SCLEROSING CHOLANGITIS

Apt. Muhammad Wisda Praja Ramdhany M.Clin.Pharm

STENT ERCP (ENDOSCOPIC RETROGRADE CHOLANGIO-
PANCREATOGRAPHY)
EPIDEMIOLOGY OF PSC

 Overall, men account for approximately two thirds of patients with PSC; but among patients with PSC without IBD,
the male predominance is much lower. Women with PSC are generally older at diagnosis.
ETIOLOGY OF PSC
SYMPTOMS

 Nearly half of adult patients with PSC present with constant or intermittent symptoms, and another 22%
develop symptoms within 5 years of diagnosis
 Symptoms of PSC include fatigue, abdominal pain, fever, and pruritus, in addition to anxiety and depression
DIAGNOSIS
MANAGEMENT OF PSC

At present, there is no approved medication for the treatment of PSC, and none has been proven to halt disease
progression. Management therefore revolves around recognizing and treating the complications of PSC when they
develop. Ultimately, LT is recommended for patients with refractory cholangitis and/or decompensated cirrhosis.
TATALAKSANA TERAPI

 Ursodeoxycholic acid

 Antibiotics
STUDI KASUS

 Pasien a/n Tn.S MRS dengan keluhan mata kuning, seluruh badan gatal. Riwayat operasi cholelithiasis. Riwayat
penggunaan obat urdahex 2x1 kapsul. TTV awal masuk TD (125/74), Nadi (86x/menit), suhu (36). Diagnosa awal masuk
IGD ( obs jaundice ec peradangan bilier ). Terapi awal IGD ( infus RL 28 tpm, inj cefoperazone 1 gram/12 jam, urdahex
2x1 kapsul ). Riwayat alergi obat (amoxixilin), Riwayat konsumsi alcohol belum dapat disangkal.
TTV DAN DATA OBJEKTIV
 Tekanan darah dari awal masuk normal

 Suhu dari awal normal (<37,5)

 BB awal 70 kg, BB tgl 30/11 menjadi (66 kg)

DATA SUBJEKTIV

 Keluhan dari awal :

1. Gatal seluruh tubuh

2. Mata kuning

3. Bab warna pucat

SOAP
SOAP
DATA OBAT
DATA LAB
DATA LAB
PEMERIKSAAN RADIOLOGI