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Predictor of Poor
Health Outcomes:
How to Manage
Roza Mulyana
Outline
● Introduction
● Albumin and hypoalbuminemia
● Hypoalbuminemia as predictor or poor outcomes
● Hypoalbuminemia management
● Conclusion
Albumin
Normal range 50% total 585 amino acids
3,5-5 g/dL plasma protein
Synthesized by
MW 66 kDa Half life 21 days liver 10-15g/day
Albumin Physiological Roles
Hypoalbuminemia
3,5 g/ dL
70% erderly hospitalized patients
hy[poalbuminemia > decrease in plasma encotic pressure >
leakage of fluid out from the vascular compartement
PATHOPHYSIOLOGY
PATHOPHYSIOLOGY
Institution:
Location:
Name of Degree / Major or Minor:
Graduation Year:
Relevant Honors or Awards:
Hypoalbuminemia predicts poor outcomes…
Management Hypoalbuminemia
Managing the
Nutrional support
underlying disease
Intravenous albumin
administration
Gatot
Ophiocephalus striatis extract increased albumin, adiponectin; decreased
TNF-α, & IL-6
Paliliewu
Supplementation of Channa striatus capsule significantly decreased TNF-α,
IFN-ү, and IL-10 levels comparednto baseline
Manfaat ophiocephalus
striatus
● Meningkatkan kadar IGF-1
● Meningkatkan kadar albumin
● Suplementasi protein
● Menrunkan IL-6
● Menurunkan TNF-α