PBL-2

Biokimia Hormon-
Hormon Kelenjar Adrenal
Christopher Christian
1806189731
DK-12
 BIOSINTESIS HORMON DI KORTEKS
ADRENAL

Sherwood L. Human physiology from cells to systems. 7th ed. Belmont: Brooks/Cole, Cengage Learning; 2010.
 BIOSINTESIS HORMON DI KORTEKS
ADRENAL

Barrett KE, Barman SM, Boitano S, Brooks H. Ganong’s review of medical physiology. 23 rd ed. United States:
TheMcGraw-Hill Companies; 2009.
 SINTESIS KORTIKOSTERONE 
ALDOSTERONE

Murray RK, Granner DK, Rodwell VW. Harper’s illustrated biochemistry. 27 th ed. United States: TheMcGraw-
Hill Companies; 2006.
 BIOSINTESIS KATEKOLAMIN

Sturm N. Catecholamines [Internet]. California: California State University; 2019 [cited 2020 Dec 9]. Available
from: http://www2.csudh.edu/nsturm/CHE450/18_Catecholamines.htm
 ALDOSTERONE (C21H28O5)

 Hormon mineralokortikoid
 Diproduksi oleh CYP11B2 (aldosterone synthase) pada zona
glomerulosa korteks adrenal
 Berikatan dengan reseptor mineralokortikoid (MR, NR3C2)
 Kompleks MR-aldosterone  retensi Na, sekresi K, reabsorbsi
air  peningkatan tekanan darah
 Keterikatan dengan protein lemah
 T1/2: 20 menit
 Tingkat aldosterone plasma normal: 0.006 g/dL (0.17 nmol/L) Aldosterone
(C21H28O5)

• Barrett KE, Barman SM, Boitano S, Brooks H. Ganong’s review of medical physiology. 23 rd ed. United States: TheMcGraw-Hill Companies; 2009.
• National Center for Biotechnology Information. Aldosterone [Internet]. Bethesda (MD): National Library of Medicine (US), National Center for Biotechnology Information;
2004 [cited 2020 Dec 9]. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/Aldosterone
 GLUKOKORTIKOID

 Diproduksi oleh zona fasciculata korteks adrenal

 Kortisol:
 Terikat pada α-globulin transcortin (corticosteroid-
binding globulin / CBG) & albumin (sedikit) Kortisol (C21H30O5)
 T1/2: 60-90 menit
 Kortikosterone:
 Keterikatan mirip kortisol tapi lebih rendah
 T1/2: 50 menit
 Kortisol & kortikosterone:
 Inaktif secara fisiologis
 Sedikit ditemukan pada urine
Kortikosterone (C21H30O4)
• Barrett KE, Barman SM, Boitano S, Brooks H. Ganong’s review of medical physiology. 23rd ed. United States: TheMcGraw-Hill Companies; 2009.
• National Center for Biotechnology Information. Corticosterone [Internet]. Bethesda (MD): National Library of Medicine (US), National Center for Biotechnology Information; 2004 [cited 2020 Dec 9].
Available from: https://pubchem.ncbi.nlm.nih.gov/compound/Corticosterone
• Royal Society of Chemistry. Cortisol [Internet]. Royal Society of Chemistry; 2020 [cited 2020 Dec 9]. Available from: http://www.chemspider.com/Chemical-Structure.5551.html
 HUBUNGAN KORTIKOL BEBAS &
TERIKAT

Barrett KE, Barman SM, Boitano S, Brooks H. Ganong’s review of medical physiology. 23 rd ed. United
States: TheMcGraw-Hill Companies; 2009.
 DEHYDROEPIANDROSTERONE SULFAT
(DHEAS)
 Disekresikan zona retikularis korteks adrenal
 Terikat pada albumin di sirkulasi
 Prekursor testosterone, adrostenedione, estradiol,
& estrone
 T1/2: 7-22 jam
 Konsentrasi memuncak pada 225 mg/dL pada usia
20-an

DHEAS (C19H28O5S)

• Barrett KE, Barman SM, Boitano S, Brooks H. Ganong’s review of medical physiology. 23 rd ed. United States: TheMcGraw-Hill Companies; 2009.
• National Center for Biotechnology Information. Dehydroepiandrosterone sulfate [Internet]. Bethesda (MD): National Library of Medicine (US), National Center for
Biotechnology Information; 2004 [cited 2020 Dec 9]. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/Dehydroepiandrosterone-sulfate
 KADAR SERUM DHEAS

Barrett KE, Barman SM, Boitano S, Brooks H. Ganong’s review of medical physiology. 23 rd ed. United
States: TheMcGraw-Hill Companies; 2009.
 KATEKOLAMIN

 Diproduksi di medulla adrenal

 50% terikat pada protein plasma (63% albumin, 13% lipoprotein),
50% bebas
 Norepinefrin
 Stimulasi reseptor adrenergic  sistem saraf simpatis Norepinefrin (C8H11NO3)
 T1/2: 2,5 menit
 Prekursor epinefrin
 Epinefrin
 Stimulasi reseptor adrenergic
 T1/2: 2-3 menit

• Barrett KE, Barman SM, Boitano S, Brooks H. Ganong’s review of medical physiology. 23 rd ed. United States: TheMcGraw-Hill Companies; 2009.
• National Center for Biotechnology Information. Norepinephrine [Internet]. Bethesda (MD): National Library of Medicine (US), National Center for Biotechnology
Information; 2004 [cited 2020 Dec 9]. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/Norepinephrine
• National Center for Biotechnology Information. Epinephrine [Internet]. Bethesda (MD): National Library of Medicine (US), National Center for Biotechnology Information;
2004 [cited 2020 Dec 9]. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/Epinephrine
Epinefrin (C9H13NO3)
 AFINITAS PADA RESEPTOR

Sherwood L. Human physiology from cells to systems. 7th ed. Belmont: Brooks/Cole, Cengage Learning; 2010.
KESIMPULAN

 Kelenjar adrenal menghasilkan beberapa jenis hormon, antara lain aldosterone,

glukokortikoid (kortisol & kortikosterone), DHEAs, & katekolamine (epinefrin &
norepinefrin)
 Hormon-hormon tersebut merupakan jenis hormon steroid, yaitu derivat kolesterol
REFERENSI

 Sherwood L. Human physiology from cells to systems. 7 th ed. Belmont: Brooks/Cole, Cengage
Learning; 2010.
 Barrett KE, Barman SM, Boitano S, Brooks H. Ganong’s review of medical physiology. 23 rd ed.
United States: TheMcGraw-Hill Companies; 2009.
 Murray RK, Granner DK, Rodwell VW. Harper’s illustrated biochemistry. 27 th ed. United States:
TheMcGraw-Hill Companies; 2006.
 National Center for Biotechnology Information. Aldosterone [Internet]. Bethesda (MD):
National Library of Medicine (US), National Center for Biotechnology Information; 2004 [cited
2020 Dec 9]. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/Aldosterone
 National Center for Biotechnology Information. Corticosterone [Internet]. Bethesda (MD):
National Library of Medicine (US), National Center for Biotechnology Information; 2004 [cited
2020 Dec 9]. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/Corticosterone
REFERENSI

 Royal Society of Chemistry. Cortisol [Internet]. Royal Society of Chemistry; 2020 [cited 2020 Dec 9].
Available from: http://www.chemspider.com/Chemical-Structure.5551.html
 Sturm N. Catecholamines [Internet]. California: California State University; 2019 [cited 2020 Dec 9].
Available from: http://www2.csudh.edu/nsturm/CHE450/18_Catecholamines.htm
 National Center for Biotechnology Information. Dehydroepiandrosterone sulfate [Internet]. Bethesda (MD):
National Library of Medicine (US), National Center for Biotechnology Information; 2004 [cited 2020 Dec
9]. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/Dehydroepiandrosterone-sulfate
 National Center for Biotechnology Information. Norepinephrine [Internet]. Bethesda (MD): National
Library of Medicine (US), National Center for Biotechnology Information; 2004 [cited 2020 Dec 9].
Available from: https://pubchem.ncbi.nlm.nih.gov/compound/Norepinephrine
 National Center for Biotechnology Information. Epinephrine [Internet]. Bethesda (MD): National Library of
Medicine (US), National Center for Biotechnology Information; 2004 [cited 2020 Dec 9]. Available from:
https://pubchem.ncbi.nlm.nih.gov/compound/Epinephrine