Quality of Recovery in Patients

undergoing Breast Conserving Therapy

after General Anesthesia: Propofol TCI
vs Inhalational Sevoflurane Anaesthesia

Dr Abdul Hannan Shahid, Resident Anesthesia, SKMCH and RC Lahore.

Dr Syed Raza Mehdi, Consultant Anesthesia, SKMCH and RC Lahore.
Dr Asma Ashraf, Consultant Anesthesia, SKMCH and RC Lahore.
Introduction:
• Early recovery from anaesthesia is desirable to hasten the patient's overall recovery and reduce prolonged
hospitalization after the procedure

• “Quality of Recovery” Score is a patient-reported outcome measure that assesses recovery after surgery

and anaesthesia

• Fifteen questions assess five domains of patient-reported health status: pain, physical comfort, physical
independence, psychological support, and emotional state
Objective
• To study and compare the quality recovery of patients undergoing Breast Conserving Therapy with Propofol
TCI and Sevoflurane as Inhalational agents using the QOR 15 questionnaire on 2 nd postoperative day
Methodology:
•STUDY DESIGN: Prospective Randomized controlled trial

•STUDY SETTING: Department of Anaesthesia, Shaukat Khanum Cancer Hospital and Research Centre,
Lahore. ,
 

• SAMPLE SIZE: A total of 74 patients included in this study divided into two groups (37 in each group,
inhalational sevoflurane and propofol TCI)
SAMPLING TECHNIQUE
• Consecutive sampling technique will be used

• All patients who meet the inclusion criteria will be randomly assigned to one of 2 groups using online
randomization software

• The patient will be blinded to the type of treatment they receive

• The attending anesthetist and surgeon will not be blinded.

Sample Selection
•Inclusion Criteria:
•1- ASA 1 or 2
•2- Age between 18 and 70
•3- Patients undergoing Breast Conserving Therapy
• 
•Exclusion Criteria:
•1- Patient refusal.
•2- History of drug allergy from the drugs being used.
•3- BMI > 30
Methodology
• After informed consent and SoC induction
• One group will be maintained on inhalational sevoflurane anesthesia (Control group)
• Other group will be maintained on TCI of Propofol (Intervention group)
• After 48 hours the patient will be contacted telephonically and QOR proforma will be filled
Standard of Care
• Patients are given general anesthesia using propofol for induction and sevoflurane for maintenance.

• Our intervention is to use TCI of propofol to the assigned group for maintenance of anesthesia.
Risks and Benefits
• Patients receiving TCI of Propofol for maintenance have better recovery and propofol itself has antiemetic
properties so postoperative nausea and vomiting risk is further reduced

• Risks are the same as with Inhalational Sevoflurane which may include hypotension.
• Patient can be allergic to propofol as it contains emulsion that includes egg lecithin and soybean oil.
Consent and Budgeting
• Written informed consent will be taken.

• Formulated as per hospital guidelines.

• Copies will be given to participants and CRO

• No additional budget is required.