OSTEOSARCO

REFERAT

MA
ANNISA MUWAFFAQ
N 111 21 110

Dokter Pembimbing :
Dr. dr. Muh. Ardi Munir Sp.OT., M.Kes., FICS., FAACT., M.H
BONE
 WHAT IS
OSTEOSARCOMA ?
• Highly malignant tumor arising from primitive
mesenchymal bone-forming cells

• Histologic hallmark is production of malignant

osteoid

• Most common histological form of primary bone

cancer

• Most common primary malignant bone tumor after

multiple myeloma

• Any bone can be involved but the most common sites

are - distal femur, proximal tibia, proximal humerus

• Most common metastasis to the lungs through blood

stream
 ETIOLOGY

● Rapid bone growth

● Radiation exposure
● Genetic predisposition :
- hereditary form of retinoblastoma (RB genemutation)
- Li-fraumeni syndrome (P53 gene mutation)
- Rothmund-- Thomson syndrome (autosomal recessive)
● Paget’s disease of bone
HISTOLOGIC
APPEARANCE
X-Ray Osteosarcoma
 INSIDENSI

More prevalent in
males than female

Involves any age but

highest occurrence in
adolescence i.e. 12-25
yers
DISTRIBUTION OF OSTEOSARCOMA
Conventional Osteosarcoma

PROXIMAL
TIBIA
Telangietatic
Osteosarcoma
Small Cell
Osteosarcoma
Low Grade Central
Osteosarcoma
Parosteal
Osteosarcoma
Periosteal Osteosarcoma
High Grade Surface
Osteosarcoma
 CLINICAL PRESENTATION

• Progressive pain particularly with activity

• Swelling > Palpable mass in the region of metaphysis

• Decreased range of motion of the involved joint

• Lymphadenopathy

• Respiratory finding

• Fever and night sweats are rare

TREATMENT
 Chemotherapy
Chemotherapy drugs that have quite
effective results for osteosarcoma are:
 doxorubicin (Adriamycin ® ),
 cisplatin (Platinol ® ),
 ifosfamide (Ifex ® ),
 mesna (Mesnex®), and
 high-dose methotrexate (Rheumatrex
® ).
TREATMENT
TREATMENT
PROGNOSIS
The prognosis of this disease is influenced by tumor size, degree of
necrosis, spread to the cortex and soft tissue penetration and weight
loss > 10 pounds.
THANK
YOU!!!