THE DIFFERENCE

BETWEEN APAPTOSIS
AND NECROSIS
 Introduction
◦ Initiating factor 
◦ Spreading
◦ Biochemical changes in cell
◦ Energy dependens 
◦ Plasmatic membrane
◦ Morphological changes in cell
◦ Elimintation of destructed cells 
◦ Nucleus
Apoptosis

Genatically determined for of cell death ,Can occur both in physiology and

pathological states , Apoptosis as a physiological process ,Occurs
throughout the life of living organism.It serves to clean tissues form cells
that have completed their physiological function and have lost significance
for the body (for example hemolysis of erythrocytes after 120
days,apoptosis of intestinal epithelial cells ,etc).In pathological condetions,
Apoptosis ensures the destruction of damaged and potentially harmful cells
(for Example : apoptosis of viruses infected cell) 
 INITIATING
FACTOR 
Degeneration of DNA under
influence of physiological and
pathological factor
SPREADING
Single cell
BIOCHEMICAL CHANGES IN
CELL
Activation of endonuclease
MORPHOLOGICA
L CHANGES
Shrinkage of cell ,thickening of
membrane condensation of
granules
ELIMENTATIO
N OF
DESTRUCTED
CELLS

Fragmentation of
cell and
phagocytosis
Nucleus Fragmatation 
Necrosis 
The pathological process that result on the death of cells and tissue under the
influence of the pathogenic factor ,There are several stages of necrosis :
paranecrosis , necrobiosis, necrosis.
Paranecrosis is the first stage of necrosis, lasts longest than other stages, and is
accompained by reversible changes in the injured cell. If favorable condition
occur, the life of a cell is restored. Necrobiosis is a short-term process, unlike the
previous one. Necrobiosis is characterized by acceleration of catabolism and
irreversible changes in the cells, during which cell injury deepens and results in
necrosis.
Necrosis means a complete cessation of cell life activity. 
Initiating factor

Destruction of plasma
membrane under
influence of pathogenic
factors 
SPREADING 
Groub of cells 
BIOCHEMICAL Activation of
CHANGES IN lysosom
enzyme
CELL
Morphological
changes in cell 
Increasing if cell size,
swelling of cytoplasma ,
destruction of membrane,
swelling of mitochondria,
lysis of granules.
 ELIMINATION OF Lysis of cells,
DESTRUCTED CELLS  phagocytosis. 
 NUCLEUS
Karyopyknosis, Karyorrhexis, Karyolysis. 
THANKS FOR
ATTENTION 
By: Somaia Moahmmed Abdelatif 
Groub number:421i-2c