Revealing the accountability of gut microbiome on the

development of chronic liver disease

Fatematuj Zohora Mohona

Exam Roll: 171972
Registration Number: 45341
Academic Session: 2016-2017
Department of Biotechnology and Genetic Engineering
 Contents

• Microbiota
1
• Interaction between microbiota and liver
2
• Role of Microbiota in liver diseases
3
• Potential of gut microbiota in treating liver disease
4
 Introduction

The gut microbiota begins to colonize almost as soon as a person is born

It plays an important part in-

Source : Internet
 Liver-microbiota interaction

The microbiota in the gut can

do several biochemical things
that can change compounds
from the lumen into secondary
metabolites.

Source : (Nielsen & Ji, 2015)

 Liver-microbiota interaction

 Metabolic activity

of microbiome

 Dysbiosis

Source : (Ostaff et al., 2013)

 Role of Microbiota in liver diseases

1 2 
Alcohol-
NAFLD and NASH associated liver
disease (ALD)

3
Chirrosis
 Role of Microbiota in liver diseases

Gut microbiome influences fat storage and insulin sensitivity, which might also result in
NAFLD .
Increased ChREBP
and
Firmicutes SREBP-1c
Bacteroidetes
Gut microbiota Increased uptake Increased Obesity NAFLD
of Lipogenesis insulisn
Dysbiosis Carbohydrates resistance

Fiaf Inhibition
I.P.I. activation

Source : (Lau et al., 2015)

 NFALD

In addition to its ability to regulate body fat growth and insulin resistance, the intestinal

microbiota appears to play a crucial role in NAFLD via multiple mechanisms, including-
 Increasing energy harvest from diet,
 altered gene expression in de novo lipogenesis,
 control of choline metabolism,
 ethanol generation,
 inflammasome and innate immunity,

 and inflammation.
 ALD

Mechanisms via which gut

dysbiosis contributes to
alcoholic liver disease

Source : (Chen et al., 2022)

 Cirrhosis

The final stage of chronic liver disease, known as cirrhosis, is marked by the development of
nodules of regenerated parenchyma, which are frequently accompanied by portosystemic
shunts”

Visual difference between

a healthy and a cirrotic liver

Source : Internet
 Potential of gut microbiota in treating liver disease

Hypothized effect
of probiotics

Source :(O’Toole & Cooney, 2008)

 Gut microbiota in treating liver disease

 Microbiome-based therapeutic

 Prebiotics

 Synbiotics

 Phage Treatment

 Antibiotics
 Conclusion

 The gut microbiota an important factor in the development of liver disorders.

 The development of sequencing technology
and culture methods has made it possible to
identify additional bacterial species,
as well as their roles and the causal linkages between them
 There is a continuing demand for additional research in
this fascinating subspecialty of hepatology.
THANK YOU