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MECHANISM OF DRUG DOESN’T DEPEND ON RECEPTOR

- Diuretics (ure, manitol): action due to increase P in renal system


- Antacids:
- Drugs used in stomachache: (Bi3+, Al3+) create a thin layer protect stomach
(phosphalugel, maalox)
- Detoxification (Dimercaptol): Chelate drugs combine with metals to treat
toxicity of As, Hg
- MgSO4: retain water in IT to help eliminate
Dose
Bioavailability
Drug distributed in Drug concentration in Drug metabolism
Pharmacokinetics
tissues circulation and elimination

Distribution Clearance

Drug concentration at
the action organ

Pharmacological action

Effects Pharmacodynamics
Clinical toxicity
Toxicology

Use

Scheme of relations of pharmacokinetics and pharmacodynamics in drug usage and action

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