Karyotype Analysis

Instructions: On the next slides, match homologous chromosomes and

arrange by size and banding pattern to diagnose a human disorder involving
abnormal numbers of chromosomes. You only need to complete ONE of the
karyotypes.

The sex chromosomes have

been colored pink (X) and
blue (Y) to help you find them.

There are three possible

disorders found in the
karyotypes:
● Down Syndrome (+21)
● Edward Syndrome (+18)
● Patau Syndrome (+13)

Human karyotype of a normal male.

Credit: Shannan Mukopf (biologycorner.com)

Set A
Set B
Set C
Set D
 Analysis Which set did you analyze? A

Patau Sydrome
1. Your karyotype indicates what disorder?
What is the sex of the person? Male

2. Chromosome number disorders are classified as

either a trisomy or a monosomy. In your case, the
extra chromosome represented the condition known Trisomy, as there was an extra
chromosome in 13.
as trisomy. Some disorders are classified as a
monosomy. Describe the difference between a
monosomy and a trisomy.

3. Use Google to search your disorder. Discuss what the symptoms of the idisorder
are and what the long term prognosis is for the person who has the disorder?

The long term prognosis is very straight forward, there are no symptoms as you are just born with it so
you usually die within a few days of birth.