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  • Uti Drugs Nitrofurans

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    Ravi Chandra
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    The document discusses urinary tract anti-infective agents, specifically nitrofuran derivatives. It notes that nitrofurazone, furazolidone, and nitrofurantoin have been used to treat bacterial infections for nearly 50 years. These compounds are derivatives of 5-nitro-2-furaldehyde formed via reaction with hydrazine or amine derivatives. Antimicrobial activity is only present when the nitro group is in the 5-position. The document also mentions metronidazole, an amebicide used to treat anaerobic bacterial infections, and provides structural diagrams of nitrofurazone, furazolidine, nitrofurantoin, and metronidazole's metabolic

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    The document discusses urinary tract anti-infective agents, specifically nitrofuran derivatives. It notes that nitrofurazone, furazolidone, and nitrofurantoin have been used to treat bacterial infections for nearly 50 years. These compounds are derivatives of 5-nitro-2-furaldehyde formed via reaction with hydrazine or amine derivatives. Antimicrobial activity is only present when the nitro group is in the 5-position. The document also mentions metronidazole, an amebicide used to treat anaerobic bacterial infections, and provides structural diagrams of nitrofurazone, furazolidine, nitrofurantoin, and metronidazole's metabolic

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    © All Rights Reserved
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    6 views9 pages

    Uti Drugs Nitrofurans

    Uploaded by

    Ravi Chandra
    The document discusses urinary tract anti-infective agents, specifically nitrofuran derivatives. It notes that nitrofurazone, furazolidone, and nitrofurantoin have been used to treat bacterial infections for nearly 50 years. These compounds are derivatives of 5-nitro-2-furaldehyde formed via reaction with hydrazine or amine derivatives. Antimicrobial activity is only present when the nitro group is in the 5-position. The document also mentions metronidazole, an amebicide used to treat anaerobic bacterial infections, and provides structural diagrams of nitrofurazone, furazolidine, nitrofurantoin, and metronidazole's metabolic

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
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    of 9

    Urinary Tract Anti-infective

    Agents

    By
    S. RAVI CHANDRA,
    ASSISTANT PROFESSOR,
    DEPARTMENT OF PHARMACEUTICAL
    CHEMISTRY,
    CHEBROLU HANUMAIAH INSTITUTE OF
    PHARMACEUTICAL SCIENCES,
    GUNTUR.
    Nitro furans
    • The first nitro-heterocyclic compounds to be introduced into chemotherapy were
    the nitro furans.

    • Three of these compounds, nitrofurazone, furazolidone, and nitrofurantoin have


    been used for the treatment of bacterial infections vastly from nearly 50 years.

    • They are derivatives of 5-nitro-2-furaldehyde, formed on reaction with the


    appropriate hydrazine or amine derivative.

    • 4th one nitro furan is Nifurtimox – antiprotozoal agent.

    • Antimicrobial activity is present only when the nitro group is in the 5-position.

    • 5th Metronidazole which is an amebicide and used for the treatment of systemic
    infections caused by anaerobic bacteria.
    Nitrofurazone

    Methenamine
    5-Nitro-2-furaldehyde semicarbazone

    Furazolidine

    3-[(5-Nitrofurylidene)amino]-2-oxazolidinone
    hexamethylenetetramine
    Nitrofurantoin

    1-(5-nitro-2-furfurylidene)-1-aminohydantoin
    METABOLISM OF NITROFURAN DERIVATIVES
    n k you
    Tha

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