https://www.ncbi.nlm.nih.

gov/
To increase the uniformity of drug distribution
in the product
2. To densify the material
3. To enhance the flow rates and rate
uniformity
4. To facilitate metering or volumetric
dispensing
5. To reduce dust
6. To improve the appearance of the product.
Roller Compaction Technology
Roll Design

Orientation

Bypass occurs because material may remain in nip region for certain,
uncontrolled time period. This also negatively affects ribbon density as well

Rough roller surface reduce the by-pass material. Types of roll surfaces are
Surface smooth, corrugated and fluted rolls.
Smooth rolls can minimize sticking problems. Corrugated rolls are therefore
particularly suitable for increasing bulk density of light, fluffy, aerated
materials.
 Feed System
Gravity: Hooper not screw

Types

Force: Hooper + screw 1 screw

2 screw
De-aeration
Air entrapped during feeding of blend to the rollers can make the ribbon weaker or brittle. Selection of
proper feeder screw helps to eliminate air entrapment issue to certain extent. To remove entrapped air
de-aeration system is sometimes used in the machines. The section consists of a sintered metal or screen that
permits air to be removed via a vacuum device

Temperature
To be partially melted and stuck to the flight
regulate screw feed rate, roll speed, pressure and
gap, vacuum de-aeration.
Compaction Force + Roller gap
exhibited a significant impact on ribbon density, granule flowability, ribbon hardness and granules content uniformity

Optimum range of screw speed depends upon powder material flow, roller speed and roller gap.
Generally the feed rate should be equal to the rate of discharge.

Roll speed:
Roll speed is inversely related to dwell time for particle compaction which affect ribbon density.
High Shear Technology
The granule particle size was increased by increasing the amount of water added, high impeller speed, and short
wet-massing time. The wet-massing time and impeller speed also had a significant impact on granulation
compressibility. Increasing the impeller speed and wetmassing time decreased granule porosity and
fragmentation propensity, which led to the decreased hardness of the finished tablets.
Extruder Screw