HAEMATOLOGY

QUIZ
VADODARA
 Q -1
ALL OF THE FOLLOWING ARE CAUSES OF
MEGALOBLASTIC ANAEMIA EXCEPT……
1. Orotic Aciduria
2. Blind Loop syndrome
3. Fanconi’s Anaemia
4. Isoniazid
 Q -2
MACROGLOSSIA IS SEEN IN…..

1. Iron deficiency anaemia

2. Megaloblastic anaemia
3. Myelofibrosis
4. Zinc Deficiency
 Q -3
NOT SEEN IN HAEMOLYTIC ANAEMIA

1. Bilirubin in Urine
2. Stercobilinogen
3. Urobilinogen
4. Decreased Haptoglobulin
 Q -4

INCREASED OSMOTIC FRAGILITY TESTS IS SEEN

IN ALL EXCEPT….
1. AIHA
2. Malaria
3. Reticulocytosis
4. PK deficiency
 Q -5

HBC IS DUE TO WHICH OF THE FOLLOWING??

1. Glutamine is replaced by Lysine at 6th. Position of beta chain of Hb A

2. Glutamine is replaced by valine at 26th. Position of beta chain of Hb A
3. Glutamine is replaced by Lysine at 26th. Position of beta chain of Hb A
4. Glutamine is replaced by valine at 6th. Position of beta chain of HbA
 Q -6

WHICH OF THE FOLLOWING IS NOT SEEN IN

SICKLE CELL DISEASE ??
1. Protection against P. Falciparum Malaria
2. Reticulocytosis
3. Increase Hb A2
4. Granulocytosis
 Q -7

CREW CUT APPEARANCE OF SKULL IS NOT SEEN

IN ??
1) Thalassemia Major
2) Haemochromatosis
3) Sickle cell disease
4) Pyruvate kinase deficiency
 Q -8

RED CELL PROTOPORPHYRINS ARE INCREASED

IN WHICH OF THE FOLLOWING??
1. Iron deficiency anaemia
2. Megaloblastic Anaemia
3. Thalassemia trait
4. Sickle Cell Disease
 Q-9

WHICH OF THE FOLLOWING IS NOT A CORRECT

COMBINATION OF EMBRYONIC
HAEMOGLOBIN??
1. Gower 1 – Z2e2
2. Gower 2 – a2e2
3. Portland 1 – Z2a2
4. Portland II – Z2b2
 Q -10
INCREASED HBF IS SEEN IN ALL OF THE
FOLLOWING EXCEPT….
1. Multiple Myeloma
2. Molar pregnancy
3. Parvovirus B19
4. Trisomy 13
 Q -11
INCREASED HBA2 IS SEEN IN ALL OF THE
FOLLOWING EXCEPT ??
1. Hyperthyroidism
2. Hb Lepore
3. Sideroblastic Anaemia
4. Megaloblastic Anaemia
 Q -12

ALL OF THE FOLLOWING ARE TRUE REGARDING

HAEMOLYTIC DISEASE OF NEWBORN
EXCEPT……
1. Direct coomb’s Test is positive in foetus
2. It is due to IgG antibodies directed against blood group antigens in foetal RBCs derived
from Maternal RBCs.
3. Direct Coomb’s Test is negative in mother
4. Anaemia is usually mild.
 Q -13

MACROANGIOPATHIC HAEMOLYTIC ANAEMIA IS

SEEN IN ALL EXCEPT….??
1) Prosthetic Heart Valves
2) March Haemoglobinuria
3) Kasabach Merrit Syndrome
4) Synthetic Vascular Grafts
 Q -14

SECOND MOST COMMON SITE OF THROMBOSIS

AFTER HEPATIC VEIN THROMBOSIS IN PNH IS??
1. Cranial veins
2. Retinal Veins
3. Deep veins of lower limbs
4. Deep veins of upper limbs
 Q -15

NOT A FEATURE OF FANCONI’S ANAEMIA

1. Hypopigmentation
2. Imperforate Anus
3. Macrocephaly
4. Hyperpigmentation
 Q -16
A CHILD WITH APLASTIC ANAEMIA IS BEING
POSTED FOR LIVER TRANSPLANT DUE TO CHRONIC
LIVER DISEASE. MOST LIKELY DIAGNOSIS IS??
1. Fanconi’s Anaemia
2. Dyskeratosis congenita
3. Schwaman Diamond syndrome
4. Pearson’s Syndrome
 Q -17
RING SIDEROBLASTS ARE DEFINED AS ?

1. Erythroblasts with 2/3rd. Of nucleus

2. Erythroblasts with /3rd. Of nucleus
3. Erythroblasts with 2/3rd. Of nucleus
4. Erythroblasts with /4th. Of nucleus
 Q -18

MOST FREQUENT CYTOGENETIC ABNORMALITY

IN PAEDIATRIC MDS IS??
1. Trisomy 8
2. Deletion 5q
3. Monosomy 7
4. Deletion Y
 Q -19

BEST WAY TO DIFFERENTIATE BETWEEN

SPURIOUS VERSUS ABSOLUTE POLYCYTHEMIA
IS ??
1. HCT
2. Red cell Mass
3. Hb
4. Oxygen saturation
 Q -20
NOT SEEN IN POLYCYTHEMIA VERA

1. Peptic Ulceration
2. Gout
3. Increased Serum Iron
4. Increased Vitamin B12 binding capacity
 Q -21

ALL OF THE FOLLOWING TUMORS ARE ASSOCIATED

WITH SECONDARY POLYCYTHEMIA EXCEPT….

1. Cerebellar Haemangioblastoma
2. Meningioma
3. Small cell carcinoma of lung
4. Pheochromocytoma
 Q -22
TREATMENT OF CHOICE FOR COLD
AGGLUTINATION DISEASE IN 2022 IS ??
1. Rituximab monotherapy
2. Bendamustine + Rituximab
3. Fludarabine + Cyclophosphamide + Rituximab
4. Steroids
 Q -23

NOT A FEATURE OF ACCELERATED PHASE OF

CML??
1. Basophilia > 20% in blood and bone marrow
2. Clonal Cytogenetic evaluation
3. Thrombocytopenia ( < 1 lacs/cumm) not responsive to therapy
4. Blast count of 15% in blood and 18% in Bone Marrow
 Q -24

NOT TRUE REGARDING MULTIPLE MYELOMA

1. Anionic Gap is decreased

2. Alkaline phosphatase is normal
3. Metastatic calcification
4. Type 1 Cryoglobulinaemia may be seen
 Q -25

HEAVY CHAIN DISEASE ASSOCIATED WITH

SMALL INTESTINAL INVOLVEMENT IS ??
1. Franklin’s Disease
2. Saligmann’s Disease
3. Mu chain disease
4. Delta chain disease
 Q -26

WHICH OF THE FOLLOWING VITAMIN K

DEPENDANT FACTORS HAVE HIGHEST HALF
LIFE??
1. Factor 10
2. Factor 11
3. Factor 12
4. Factor 13
 Q -27

NOT TRUE IN WISCOTT ALDRICH SYNDROME

1. IgM is Increased
2. X linked recessive
3. IgE is increased
4. Decreased T cells
 Q -28

SHELF LIFE OF ACID CITRATE DEXTROSE

ADENINE BUFFER IS??
1. 35 days
2. 21 days
3. 7 days
4. 10 days
 Q -29

WHICH OF THE FOLLOWING IS CONSIDERED AS

APLA SYNDROME
1. 2 deaths of morphologically normal foetus at 4 weeks of gestation
2. 3 premature births at 36 weeks of gestations due to preeclampsiae
3. More than 3 unexplained consecutive spontaneous abortions at 12 weeks of gestation
4. 8 miscarriages after 12 weeks of gestation
 Q -30

NOT A COMPLICATION OF MASSIVE BLOOD

TRANSFUSION?
1. Metabolic Acidosis
2. Metabolic Alkalosis
3. Increase in 2,3 DPG
4. Coagulopathy