Presentation of ME 400: Project & Thesis

Study of Cardiovascular System

Using Time Variance Elastance Model

Tasfin Ahmed (1510082)

Mushfiq Ahmad Siddiqui(1510141)

Under the Supervision of

Dr. Sheikh Mohammad Shavik
Assistant Professor
Department of Mechanical Engineering, BUET

October 17, 2021

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Introduction

 Cardiovascular System: Divided

into (i) Systemic vascular
System and (ii) Pulmonary
Vascular System
 Pressure Volume Loop

Figure: Block diagram of

Cardiovascular System

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Time Varying Elastance Model

 Widely used to simulate left

ventricular function
 independent of ventricular preload
and afterload
 Used to find the marker of the
contractility of the LV
Relation between Pressure
and Volume in the model,
P(t)= E(t)[V(t) – V0]

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Objectives

 Design models of Systemic and Pulmonary

Circulation
.
 Generate Pressure Volume graphs

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Mathematical Formulation and Physical Modeling

From the data obtained from the time varying elastance model we can
get the values of pressure generated in Left and Right Ventricle,

For Left Ventricle,

PLV(t) = e(t)PLVES(VLV) + [1 - e(t)]PLVED(VLV)

For Right Ventricle,

PRV(t) = e(t)PRVES(VRV) + [1 - e(t)]PRVED(VRV)

The rate of change in V was calculated assuming conservation of mass,

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Equations

For Closed-Loop Systemic Circulatory Model,

= qven (t) - qmv (t);

= qmv (t) - qao (t);
= qao (t) - qper (t)
= qper(t) - qven(t);

qao(t)=

qper(t)=;
qven(t)= ;

qmv(t)= ;

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Equations

For Closed-Loop Pulmonary Circulatory Model,

= qvc(t) - qtv(t);
= qtv(t) - qpv(t);
= qpv(t) - qper(t);
= qper(t) - qvc(t);

qpv(t)= ;
qper(t)=;
qven(t)= ;
qtv(t)=

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COMPUTATIONAL METHOD

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Results & Discussion

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Results & Discussion

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Results & Discussion

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Results & Discussion

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Results & Discussion

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Results & Discussion

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Results & Discussion

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Conclusion

The goal of this study was to develop models for both systemic
circulatory system and pulmonary circulatory system. After
generating the model, we ran some analysis to get the graphs
where it shows the pressure and volume of the circulation system
parts. By analyzing those graphs, we can get some idea about the
model of our heart. The model parameters can be further tweaked
to simulate heart in different conditions.

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References

• Sheikh Mohammad Shavik, Zhenxiang Jiang, Seungnik Baek, Lik Chuan Lee.
High spatial resolution multi-organ finite element modeling of ventricular-arterial
coupling. Department of Mechanical Engineering, Michigan State University, East
Lansing, MI, United States, 2018.
• Daniel Burkhoff, MD, PhD. Mechanical Properties of the Heart and its interaction with
Vascular System. Columbia University, 2002.
• Roy R Ha, Junhui Qian, David L Ware, Joseph B Zwischenberger, Akhil Bidani, John W
Clark. An Integrative Cardiovascular Model of the Standing and Reclining Sheep.

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Thank you for your attention

Questions on this presentation are welcomed.

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