KONSEP REAKSI ORGANIK-3

SUPRIANTO, S.Si., M.Si., Apt

 KONDENSASI
1.a. KONDENSASI ALDOL
O O

CH3CH2 C H + CH3 C H

O O
Na OH
CH2 C H CH2 C H

O O OH O
H
CH3CH2 C H + CH2 C H CH3CH2 C CH2 C H

H2O O

CH3CH2 CH CH C H
 2.b. KONDENSASI CLAISEN
O O

CH3CH2 C O CH2CH3 + CH3 C O CH2CH3

O O
Na OEt
CH2 C O CH2CH3 CH2 C O CH2CH3

O O
H
C
CH3CH2 OCH2CH3 + CH2 C O CH2CH3
O O

CH3CH2 C CH2 C O CH2CH3 + CH3CH2O H

Rainer Ludwig Claisen (1851-1930). Developed the “Claisen Condensation” in 1887
KONVERSI GUGUS FUNGSI
R C N
H2O
O

R C OH
R’OH OH- O
O H2O
H2O SOCl2 R C O
R C OR’ R’OH
O OH-
NH3 NH3 RCOOH
R C Cl
NR’2H NR’2H H O
2
RCOOH
O NH3
NR’2H O O
R C NH2
O R C O C R
NH3
R C NR’2 NR’2H
 NO 2
X
X2
HNO 3
FeX3 AlCl 3 H2SO 4
RX
R
O Al Cl 3
H2SO 4
R C X O

SO 3H [O] C R
COOH