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K9-Skin Infections.
K9-Skin Infections.
Obligate pathogens
• Mycobacterium. tuberculosis - TB
• Mycobacterium bovis - bovine TB
• Mycobacterium. leprae - Hansen's disease (leprosy)
Emerging Diseases
• Hansen’s Disease(1873) – Leprosy
• caused by Mycobacterium leprae
• large amounts of mycolic acids on the cell
surface
• multiplies very slowly
• mostly infects skin, nerves and mucous
membranes
• never cultivated in laboratory media or cell
culture, but has been cultivated in mouse
foot pads
Emerging Diseases
• Leprosy
• route of infection is not known, but probably via
respiratory droplets
• most people are resistant and do not develop active
disease
Transmissions:
Long and close contract with lepromateous patients
Nasal secretion
Skin lesions
Inhalation
Emerging Diseases
Low TT BT BB BL LL High
Poor prognosis
Emerging Diseases
• Borderline Leprosy
• few to many bacilli in skin smears
• Borderline Leprosy
Tuberculoid leprosy:
Dapsone combined with rifampin
Lepromatous leprosy:
Dapsone, rifampin and clofazimine
B. Zoster:
• Infeksi akut pada syaraf & dorsal root ganglion
• Inflamasi& nyeri hebat pd ganglia unilateral pada badan,
kepala & leher.
Human herpes virus 6
• T- lymphtropic HHV 6: 1986.
• GK: exanthema subitum pd infant (roseola infantum)
demam, skin rash.
# Host :
- variola : only humans & monkeys
- vaccinia : broad host range, including
rabbits & mice
# Grow on chorioallantoic membrane of 10-12 days
old chick embryo, but variola produces much
smaller pocks
# Grow in several types of chick & primate cell
lines
Pathogenesis of smallpox: