THE EFFECT OF GINGER

SUPPLEMENTATION ON IMMUNITY
AND INFLAMMATION MEDIATED GENE
EXPRESSION IN PATIENTS WITH
ACTIVE RHEUMATOID ARTHRITIS
 GROUP MEMBERS

Armeen Fatima Qamar 2020-ND-001

Affaf Mahnoor 2020-ND-002
Aiza Tahir 2020-ND-039
Noor-us-Sabah 2020-ND-050
 OBJECTIVE

•RA: Chronic autoimmune disease

characterized by joint inflammation and
damage.
•Managing inflammation and modulating
immune responses are crucial for RA
patients.
•Natural compounds like ginger have
shown potential in reducing inflammation
and modulating gene expression.
 METHOD

• Randomized double-blind placebo-controlled clinical trial.

• Seventy active RA patients randomly allocated into two groups:
• Ginger group: Received 1500 mg of ginger powder daily.
• Placebo group: Received inert substance.
• Duration: 12 weeks.
• Disease activity score and gene expression measured before and after
the intervention.
• Gene expression of NF-κB, PPAR-γ, FoxP3, T-bet, GATA-3, and
RORγt assessed using quantitative real-time PCR
 RESULT

Main Findings: Effect of Ginger Supplementation on Gene Expression and

disease Activity.
1. Gene Expression:
• FoxP3:
• Significant increase in expression within the ginger group (P-value = 0.02).
• Significant difference in expression between the ginger and placebo groups (P-value =
0.02).
• T-bet and RORγt:
• Significant decrease in expression between the ginger and placebo groups (P-value < 0.05).
• PPAR-γ:
• Significant increase in expression within the ginger group (P-value = 0.047).
• Non-significant difference in expression between the ginger and placebo groups (P-value =
0.12).
 RESULT

2.Disease Activity Score:

• Reduction in disease activity score:
• Significant reduction within the ginger group.
• Significant difference in reduction between the ginger and placebo groups
 CONCLUSION

• Ginger supplementation appears to improve rheumatoid arthritis by

modulating gene expression associated with immune regulation and
inflammation.
• Increased FoxP3 expression and decreased RORγt and T-bet expression
contribute to the observed improvements in disease manifestations .
THANK YOU