TESTIS SEMINOMA Embryonal carcinoma. Tumor architecture is variable. Tumor cells often grow in diffuse sheets and may be arranged to resemble poorly formed glands. Tumor cells are large and tend to overlap one another, and cell membranes are difficult to discern, lending a syncytial appearance to the tumor. Tumor cell nuclei are vesicular with irregular outlines, coarse chromatin, and prominent nucleoli. Mitotic figures and apoptotic cells are abundant Schiller-Duval bodies
Yolk sac tumor.
The endodermal sinus pattern of yolk sac tumor is characterized by the presence of irregular interconnecting labyrinthine-like spaces and Schiller-Duval bodies, several of which are nicely illustrated (lower right) Choriocarcinoma. The multinucleated syncytiotrophoblasts have voluminous eosinophilic cytoplasm and large darkly staining irregular nuclei with prominent nucleoli. The smaller mononuclear cytotrophoblasts are fairly uniform in size. They have modest amounts of clear to amphophilic cytoplasm; they bear some resemblance to the tumor cells of solid yolk sac tumor Benign prostatic hyperplasia. The acini are lined by columnar secretory cells. The basal cell layers may be inconspicuous, but can be highlighted readily by high molecular weight cytokeratin immunostains
Benign prostatic hyperplasia,
stromal nodule. This nodule is composed of stromal cells with myxoid degeneration Adenokarsinoma Prostat Gleason’s Pattern 2 Gleason’s Pattern 5