Scribd Logo
Upload

Welcome to Scribd!

  • AED Mechanism of Action

    Uploaded by

    KAMLESH RATHOD
    10 views11 pages
    AEDs work through different mechanisms of action such as enhancing GABA transmission, blocking sodium and calcium channels, or interfering with glutamate signaling. Barbiturates prolong the effect of GABA on chloride channels. Benzodiazepines increase the frequency of GABA-mediated chloride channel openings. Ethosuximide blocks calcium channels in thalamic neurons. Valproate has multiple mechanisms including enhancing GABA transmission, blocking sodium and calcium channels. Topiramate blocks sodium channels and modulates GABA and glutamate signaling.

    Original Description:

    Copyright

    © © All Rights Reserved

    Available Formats

    PPTX, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Report this Document
    AEDs work through different mechanisms of action such as enhancing GABA transmission, blocking sodium and calcium channels, or interfering with glutamate signaling. Barbiturates prolong the effect of GABA on chloride channels. Benzodiazepines increase the frequency of GABA-mediated chloride channel openings. Ethosuximide blocks calcium channels in thalamic neurons. Valproate has multiple mechanisms including enhancing GABA transmission, blocking sodium and calcium channels. Topiramate blocks sodium channels and modulates GABA and glutamate signaling.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    10 views11 pages

    AED Mechanism of Action

    Uploaded by

    KAMLESH RATHOD
    AEDs work through different mechanisms of action such as enhancing GABA transmission, blocking sodium and calcium channels, or interfering with glutamate signaling. Barbiturates prolong the effect of GABA on chloride channels. Benzodiazepines increase the frequency of GABA-mediated chloride channel openings. Ethosuximide blocks calcium channels in thalamic neurons. Valproate has multiple mechanisms including enhancing GABA transmission, blocking sodium and calcium channels. Topiramate blocks sodium channels and modulates GABA and glutamate signaling.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 11

    AEDs

    Mechanism of action
    Mechanism of action of anti-epileptic drugs (Apr ’18)
    AEDs MOAs

    Barbiturates
    • Prolong GABA-mediated chloride channel openings

    Benzodiazepines
    • Increase frequency of GABA mediated chloride channel openings

    Ethosuximide
    • Blocks slow, threshold, “transient” (T-type) calcium channels in thalamic neurons
    Multiple MOAs
    Valproate
    • May enhance GABA transmission in specific circuits
    • Blocks voltage-dependent sodium channels
    • Blocks T-type calcium currents

    Topiramate
    – Blocks voltage-dependent sodium channels at high firing frequencies
    – Increases frequency at which GABA Cl channels opening
    (different site from benzodiazepines)
    – Antagonizes glutamate actions at receptor subtype
    AEDs MOAs
    Vigabatrin
    Irreversibly inhibits GABA transaminase

    Tiagabine
    Interferes with GABA re-uptake

    Gabapentin
    modulate amino acid transport into brain
    interfere with GABA re-uptake

    You might also like