TOXIDROMS

Toxic syndroms= ensemble of clinical

signs and symptoms due to a toxic
TOXIDROMS :
1.SIMPATOMIMETIC
2.ANTICHOLINERGIC
3.CHOLINERGIC
4.OPIOID
5.HYPNOTIC-SEDATIVE
6.WITHDRAW
 SIMPATOMIMETIC TOXYDROM

FIGHT or RUN- sympatheic autonomic system

alfa and beta receptors are activated and caused simpatetic effects as:
midriasis, diaphoresis, tachycardia, hypertension, increased or normal bowel sound, agitation, hyperthermia.
-SIMPATICOMIMETICS : COCAINE, AMPHETAMINE, ADRENALINE, EFEDRINE.
Treatment: - decrease the body temperature- cooling methods
-sedation
- treatment of high BP- BUT DO NOT USE Beta Blockers (produce increasing alfa1 effect)
ANTICHOLINERGIC TOXYDROM

-tachycardia, hypertension; midriasis, hyperthermia, decreased bowel sound, urinary retention,

hallucination
Anticholinergic substances: Benadryl
Treatment of anticholinergic toxydrom:
-sedation using Benzodiazepine
-Fizostygmine
-seizures treatment
- urinary catheter
 CHOLINERGIC TOXYDROM

-parasimpathetic autonomic system

- hyperlacrimation, hypersalivation, diarhoeea, urine incontinence, vomits,
-bradycardia, bronchoreea, bronchospasma
-Substances: anticholinesterazic insecticedes, organo-phosphorates, fight gases
Treatment: ABCD, support vital function, Atropine IV, Pralidoxime
OPIOID TOXYDROM

Morphine, Petidine, Pentazocine, Heroine

-Clinical signs; miosis, respiratory depression, decreased level of counscioussnes, hypotension,
bradycardia
- treatment: sustaine vital function, use the antidote: NALOXONE
HYPNOTIC – SEDATIVE
TOXYDROM
-COMA / REDUCED LEVEL OF COUNSCIOUS
-vital function to be sustained
-antidotes if there exist- ex Flumazenil for benzodiazepine
WITHDRAW TOXYDROM= SEVRAGE SYNDROM

Opioid withdraw syndrom:nausea, vomits, diarrhoeea, diaphoresis, piloerection.

Withdraw syndrome to sedative-hypnotics: nausea, vomits, diarrhoeea, diaphoresis,
piloerection, halucination, delirium, tremor, seizures, autonomic nervous system instability.
TOXIDROMES