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  • Solubility Minggu 14

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    Wndy 0903
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    Solubility of drugs can be influenced by particle size. Smaller drug particles have a larger surface area that allows for more contact with the solvent, increasing dissolution and solubility. One study showed that decreasing the particle size of phenobarbital increased its solubility in an alcohol-glycerol-water system at 25°C. Common references on solubility and related topics are cited.

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    Solubility minggu 14

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    Solubility of drugs can be influenced by particle size. Smaller drug particles have a larger surface area that allows for more contact with the solvent, increasing dissolution and solubility. One study showed that decreasing the particle size of phenobarbital increased its solubility in an alcohol-glycerol-water system at 25°C. Common references on solubility and related topics are cited.

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    5 views6 pages

    Solubility Minggu 14

    Uploaded by

    Wndy 0903
    Solubility of drugs can be influenced by particle size. Smaller drug particles have a larger surface area that allows for more contact with the solvent, increasing dissolution and solubility. One study showed that decreasing the particle size of phenobarbital increased its solubility in an alcohol-glycerol-water system at 25°C. Common references on solubility and related topics are cited.

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    SOLUBILITY

    Kuncoro Foe
    REFERENCES
     Martin, Physical Pharmacy
     Remington’s Pharmaceutical Science
     Sprowl, Prescription Pharmacy
     Husa’s Dispensing of Medication
     Burlage, Physical Pharmacy
     Lachman, Industrial Pharmacy
     Scoville
    Influence of Particle Size on
    Drug Solubility
    Phenobarbital solubility (% w/v) in
    alcohol – glycerol – water system
    (25  0.1ºC)
    Thank You

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